A two part study utilizing polyoxymethylene (POM) was undertaken to investigate a three stage process (melt-extrusion/annealing/uniaxial-stretching) (MEAUS) utilized to produce microporous films. In this report, the thermal annealing (second stage) and subsequent uniaxialstretching (third stage) results of selected POM films from two commercial resins, labeled D & F, are discussed. Specifically...

Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, NH-58, Baghpat Road-Bypass Crossing, Meerut-250005 (U.P), India ABSTRACT Drug release from mucoadhesive patches at predetermined rate in oral cavity having distinct advantages over traditional dosage forms as tablets, gels and solutions. This review provides brief information about method of preparation and e...

Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targ...

In pharmaceutical industries, pellets are multiparticulate dosage form which was formed by the agglomeration of fine powdered excipient and drugs together that leads to the formation of small free flowing spherical or semi spherical particles. This technique is called as pelletization process. Pellets are typically varied between 500-1500 μm in size for pharmaceutical applications. It is of gre...

The purpose of this study was to evaluate the performance of synthetic magnesium aluminometasilicate (MAS) as a novel inorganic carrier in hot melt extrusion (HME) processing of indomethacin (IND) for the development of solid dispersions. A continuous extrusion process at various IND/excipient blend ratios (20%, 30% and 40%) was performed using a twin-screw extruder. Physicochemical characteriz...

During the developmental process, there is an estimated 40 to 70% incidence of delay or failure for new drug entities due to poor biopharmaceutical properties such as poor solubility, poor permeability and poor chemical stability. Hot melt extrusion (HME) technology may provide the answer. HME, a solid-dispersion technology, has gained popularity in the pharmaceutical industry as a means of imp...

Following the recent success of hot-melt extrusion in the pharmaceutical field, monitoring and control are increasingly applied. In this study, a mathematical model consisting of mass and energy balance partial differential equations is developed and parameters related to material transportation are inferred from experimental data collected from a pilot plant. This data is relative to the outpu...