The author discusses the health risks associated with early menopause and benefits of hormone replacement therapy to mitigate these alleviate hypoestrogenic symptoms as appropriate for individual patients.

The role of estrogens in the prevention of cardiovascular disease is currently of particular interest. Recently, Wenger1 reviewed various randomized clinical trials to assess the effect of hormone replacement therapy in cardiovascular disease and concluded that postmenopausal hormone therapy does not prevent clinical cardiovascular events in healthy women or women with heart disease. The questi...

Cardiovascular disease is the leading cause of death in postmenopausal US women. The contribution of postmenopausal hormone replacement therapy to cardiovascular risk is one of the most controversial women's health topics. Strikingly discordant results, between observational and randomized clinical trials, have been reported. Remaining questions regarding time of hormone therapy initiation are ...