The honest polynomial-time Turing (hp-T) reducibility, < :p, was first introduced by Homer (e.g. [6)). It has been known that the structural properties of the hp-T degrees of the recursive sets and those of the A; sets are closely related to the P =?NP problem. Homer [6,7] and Homer and Long [S] proved assuming P=NP that there is a As set which is <p minimal, and then Ambos-Spies [2] improved t...

Contact: [email protected] PHD protein secondary structure analysis software is a neural-network based method, rating at an expected average accuracy ∼72% for the three states helix, strand and loop when using multiple alignment input (Rost and Sander, 1993a,b, 1994). Using the PHD also allows the prediction of solvent accessibility (i.e. surface exposure) of individual amino-acid...

Normal aging is associated with impairments in cognition, especially learning and memory. However, major individual differences are known to exist. Using the classical Morris Water Maze (MWM) task, we discriminated a population of 24-months old Long Evans aged rats in two groups--memory-impaired (AI) and memory-unimpaired (AU) in comparison with 6-months old adult animals. AI rats presented def...

Glaucoma is a multifactorial progressive ocular pathology, clinically presenting with damage to the retina and optic nerve, ultimately leading to blindness. Retinal ganglion cell loss in glaucoma ultimately results in vision loss. Vesl/Homer proteins are scaffolding proteins that are critical for maintaining synaptic integrity by clustering, organizing and functionally regulating synaptic prote...

It is known that the design of each power system is a complex task. This fact holds true for micro-power systems too. Design solution should provide the answers to some complex issues related to the need to include certain components, their cost, efficiency, size and configuration of the system that can be used. It is known that when designing a system, in this case the energy system, it is nec...

In rat sympathetic neurons from the superior cervical ganglia (SCG) expressing metabotropic glutamate receptors (mGluRs) 1 or 5, overexpression of scaffolding Homer proteins, which bind to a Homer ligand in their C-termini, cause receptor clustering and uncoupling from ion channel modulation. In the absence of recombinant Homer protein overexpression, uncoupling of mGluRs from voltage dependent...

AIM This study was conducted to find the best suited freely available software for modelling of proteins by taking a few sample proteins. The proteins used were small to big in size with available crystal structures for the purpose of benchmarking. Key players like Phyre2, Swiss-Model, CPHmodels-3.0, Homer, (PS)2, (PS)(2)-V(2), Modweb were used for the comparison and model generation. RESULTS...

At hippocampal excitatory synapses, endocannabinoids (eCBs) mediate two forms of retrograde synaptic inhibition that are induced by postsynaptic depolarization or activation of metabotropic glutamate receptors (mGluRs). The homer family of molecular scaffolds provides spatial organization to regulate postsynaptic signaling cascades, including those activated by mGluRs. Expression of the homer 1...

There is a need to develop an optimization tool that can be applied in the feasibility study of hybrid renewable energy system find optimal capacity different resources and support decision makers their performance investigation. A multi-objective function which minimizes Levelized Cost Energy (LCOE) Loss Load Probability Index (LLPI) but maximizes novel Match Ratio (EMR) was formulated. Simula...

Striated muscle represents one of the best models for studies on Ca(2+) signalling. However, although much is known on the localisation and molecular interactions of the ryanodine receptors (RyRs), far less is known on the localisation and on the molecular interactions of the inositol trisphosphate receptors (InsP(3)Rs) in striated muscle cells. Recently, members of the Homer protein family hav...