نتایج جستجو برای: homed
تعداد نتایج: 423 فیلتر نتایج به سال:
Compartmentalization of immunity ensures tight regulation of T cell activation in the LN and precise effector T cell delivery to inflamed sites. Herein we show that the tissue-specific accumulation of effector T cells can be subverted by a pathogen at the infection site. Using the Leishmania major mouse model of dermal infection, we observed a restricted chemokine profile at the infection site,...
Certain popular metrics have been used to reflect the instability of the Internet control plane, such as the volume and duration of BGP updates. However, it is unclear whether there is a direct relationship between those metrics and the data plane performance, especially as the Internet is becoming more densely connected and many networks become multi-homed. To clarify this, we measured data st...
Content-centric networking (CCN) adopts a receiver-driven, hop-by-hop transport approach that facilitates in-network caching, which in turn leads to multiple sources and multiple paths for transferring content. In such a case, keeping a single round trip time (RTT) estimator for a multi-path flow is insufficient as each path may experience different round trip times. To solve this problem, it h...
TCP and UDP are the most popular transport protocols used for end-end data transmission. The rapid growth of internet leads to development of many innovative applications in the current environment. Depending on the functionality of these applications, requirements of transport protocols are changing. TCP is known for its problems with Head Of Line blocking (HOL) and SYN attacks which gives red...
The abnormal trafficking of CD34+ cells is a unique characteristic of primary myelofibrosis (PMF). We have further studied the behavior of PMF CD34+ cells by examining their homing to the marrow and the spleens of nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. Following the infusion of PMF and normal granulocyte colony-stimulating factor-mobilized peripheral blood (mPB) CD34...
Neoplastic epithelia may remain dormant and clinically unapparent in human patients for decades. Multiple risk factors including mutations in tumor cells or the stromal cells may affect the switch from dormancy to malignancy. Gene mutations, including p53 mutations, within the stroma of tumors are associated with a worse clinical prognosis; however, it is not known if these stromal mutations ca...
The normalized Laplacian spectrum (NLS) is a powerful tool for comparing graphs with different sizes. Recently, we showed that two NLS features, namely the weighted spectral distribution (WSD) and the multiplicity of the eigenvalue 1 (ME1), are particularly relevant to the Internet topology at the inter-domain level. In this paper, we examine the physical meaning of the two metrics for the Inte...
Homing to secondary lymphoid organs and bone marrow (BM) is a central aspect of leukemic pathophysiology. We investigated the roles of the two major lymphocyte integrins LFA-1 and VLA-4 on B-cell chronic lymphocytic leukemia (CLL) cells in these processes. We found that the majority of CLL cells expressed significantly reduced LFA-1 due to low beta2 integrin transcripts. VLA-4 expression was he...
Status of this Memo This memo provides information for the Internet community. It does not specify an Internet standard of any kind. Distribution of this memo is unlimited. 2. Abstract This document describes addressing and routing strategies for multi-homed enterprises attached to multiple Internet Service Providers (ISPs) that are intended to reduce the routing overhead due to these enterpris...
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