Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting 5-10% of premenopausal women. 50-90% characterized by insulin resistance. Obesity is common among patient with PCOS. Objective: To investigate insulin resistance (IR) and β cell function (βF) in upper body obese women with PCOS. Materials and Methods: 51 Iraqi women with PCOS and 25 healthy age-matched cont...

Childhood obesity is a global health problem with several metabolic and cardiovascular complications. The prevalence of childhood and adolescent obesity is differed in each country with several affecting factors. Insulin resistance as one common feature of obesity is known to have a link with the risk of diabetes type 2 and cardiovascular complication. Insulin resistance is also a basic mechani...

Amaç: Tip 2 diyabet (T2D), diyabetin en sık görülen türüdür ve tüm dünyada olduğu gibi ülkemizde de ciddi bir halk sağlığı sorunu haline gelmiştir. İnsülin sekresyonunun azalması ve/veya insülin direnci (İR) gelişimi, T2D patogenezinde yer alan iki ana bozukluktur. Kromozom 3p25'te peroksizom proliferatör aktive reseptör gama (PPARG) geni tarafından kodlanan esas olarak adipositlerde eksprese e...

UNLABELLED BACKGROUND Sirtuins are important regulators of glucose and fat metabolism, and sirtuin activation has been proposed as a therapeutic target for insulin resistance and diabetes. We have shown leucine to increase mitochondrial biogenesis and fat oxidation via Sirt1 dependent pathways. Resveratrol is a widely recognized activator of Sirt; however, the biologically-effective high con...

A high-carbohydrate low-fat (HC/LF) diet and lipoprotein lipase gene (LPL) Ser447Stop and Hind III polymorphisms have separately been found to be associated with triacylglycerol (TG) and high density lipoprotein cholesterol (HDL-C). This study sought to test the effects of LPL polymorphisms and an HC/LF diet on the serum lipid profile of Chinese with a lower incidence of coronary artery disease...

Significant reductions in insulin resistance (IR) can be achieved by either calorie restriction or by the increase of lean mass. However, calorie restriction usually results in significant loss of lean mass. A 6-week randomized controlled feeding trial was conducted to determine if a calorie-restricted, high-protein diet (~125 g protein/day consumed evenly throughout the day) using novel functi...

Background/Aim. Adiponectin exerts profound protective actions during insulin resistence or prediabetes progression towards more severe clinical entities such as metabolic syndrome and/or cardiovascular disease. Since hypoadiponectinaemia contributes to the pathophysiology of the metabolic syndrome and coronary artery disease the level of circulating adiponectin may be an early marker of cardio...

Type 2 diabetes (T2D) has been studied for decades. Many risk factors of T2D have been identified, but few studies were designed to investigate the pharmacokinetics/ pharmacodynamics (PK/PD) risk factors preceding the onset of T2D. Moreover, although the disease progression of T2D has received considerable attention, little is known about the disease development of T2D. It is important to under...

Background: Sitagliptin has been used as oral hypoglycemic agents and widely used for treatment of type 2 diabetes mellitus (T2DM). Objectives: The study aimed to explore the correlation of transforming growth factor-β1 (TGF-β1) and Platelet derived growth factor-BB (PDGF-BB) in regulation of urinary albumin excretion rate (UAER). Material and method: 164 patients with type 2 diabetic nephropat...

INTRODUCTION Differences in neonatal insulin sensitivity/ resistance markers due to the maternal impaired glucose tolerance (IGT) have not been tested. The Healthy Eating Index (HEI) score has been employed for evaluating pregnancy diet quality. AIMS To study, the effect of neonatal insulinemia, maternal IGT and diet HEI score upon insulin sensitivity/ resistance at birth. METHODS 176 singl...