Background: Intermittent cold stress delays flowering. This results from interaction between the cold and photoperiodic pathways. Results: CO protein is degraded through an HOS1-mediated ubiquitination mechanism during brief cold treatments. Conclusion: CO acts as a molecular hub that integrates photoperiod and cold signals into the flowering genetic pathways. Significance: The CO-HOS1 module i...

One of the most significant and well-known properties of entangled states is that they may lead to violations of Bell inequalities and are thus inconsistent with any local-realistic theory. However, there are entangled states that cannot violate any Bell inequality, and in general the precise relationship between entanglement and observable nonlocality is not well understood. We demonstrate tha...

Holt-Oram syndrome is an autosomal-dominant condition characterized by congenital cardiac and forelimb anomalies. It is caused by mutations of the TBX5 gene, a member of the T-box family that encodes a transcription factor. Molecular studies have demonstrated that mutations predicted to create null alleles cause substantial abnormalities in both the limbs and heart, and that missense mutations ...

A multipartite quantum state violates a Bell inequality asymptotically if, after jointly processing by general local operations an arbitrarily large number of copies of it, the result violates the inequality. In the bipartite case we show that asymptotic violation of the Clauser-Horne-Shimony-Holt inequality is equivalent to distillability. Hence, bound entangled states do not violate it. In th...

We show that an experimental demonstration of quantum contextuality using 2 degrees of freedom of single neutrons based on a violation of an inequality derived from the Peres-Mermin proof of the Kochen-Specker theorem would be more conclusive than those obtained from previous experiments involving pairs of ions [M. A. Rowe, Nature (London) 409, 791 (2001)10.1038/35057215] and single neutrons [Y...

We observe entanglement between photons in controlled super-position states of orbital angular momentum (OAM). By drawing a direct analogy between OAM and polarization states of light, we demonstrate the entangled nature of high order OAM states generated by spontaneous downconversion through violation of a suitable Clauser Horne Shimony Holt (CHSH)-Bell inequality. We demonstrate this violatio...

A locally causal hidden-variable theory of quantum physics need not be constrained by the Bell inequalities if this theory also partially violates the measurement independence condition. However, such violation can appear unphysical, implying implausible conspiratorial correlations between the hidden variables of particles being measured and earlier determinants of instrumental settings. A nove...

Recent studies have identified the genetic underpinnings of a growing number of diseases through targeted exome sequencing. However, this strategy ignores the large component of the genome that does not code for proteins, but is nonetheless biologically functional. To address the possible involvement of regulatory variation in congenital heart diseases (CHDs), we searched for regulatory mutatio...