The successful adaptation of the duck (Anas platyrhynchos) to a diet containing hypertonic saline as drinking water involves many complex changes in the excretory mechanisms of the bird (Fletcher & Holmes, 1968; Fletcher, Stainer & Holmes, 1967; Holmes, Fletcher & Stewart, 1968; Holmes & Stewart, 1968). These changes include modifications of the renal excretory pattern such that at least part o...

Positive selection in the human immunodeficiency virus type 1 (HIV-1) env gene has been demonstrated by comparisons of the abundance of nonsynonymous (dn) and synonymous (ds) pairwise variability in the DNA sequence (Bonhoeffer, Holmes, and Nowak 1995; Seibert et al. 1995; Yamaguchi and Gojobori 1997). An increase in dn above the neutral expectation of dn # ds provides an unambiguous indication...

Among the different notions of area in a Minkowski space, those due to Busemann and to Holmes and Thompson, respectively, have found particular attention. In recent papers it was shown that the Holmes-Thompson area is integral-geometric, in the sense that certain integral-geometric formulas of Croftontype, well known for the area in Euclidean space, can be carried over to Minkowski spaces and t...

the subjective perception of neurological deficit; and with the disorders of vision. Thus, one essay examines sociological aspects of aphasia, another the detection of minimal dysphasia, and others the evolution and possible future of language. His exploration of the relationship between the language of schizophrenics and that of aphasics is particularly fascinating. Other essays deal with miso...

As prescribed by a few methodologies the Software Product Lines consist of Domain Engineering (DE) and Application Engineering (AE). One of the major problems when performing DE is to keep the information pertaining to the different phases of DE in synchronization. The existing CASE tools have achieved full support for change propagation between the design phase and the implementation phase. St...