Based on the successful clinical experience with the anti-CD20 antibody, rituximab, for the treatment of B-cell non-Hodgkins lymphoma, there is a rapidly growing literature on the treatment of patients with autoimmune diseases with this therapeutic agent. However, the pathogenetic mechanisms responsible for these diseases may differ greatly from those in B cell malignancies. Herein, I provide a...

Rituximab (Rituxan) is a genetically engineered chimeric murine/human monoclonal antibody and the first monoclonal antibody to become available to physicians for the treatment of malignant disease. It has recently been licensed for use in the treatment of patients with relapsed or refractory low-grade or follicular, CD20 positive B-cell Non-Hodgkins Lymphoma (NHL). Its mechanism of action is by...

[as found here: http://www.medicalgeo.com/Med-Diseases-L/Lymphoma.html] Lymphoma A general term for malignancies of lymphocytes or, more rarely, of histiocytes. Collectively, these cell types non hodgkins lymphoma symptoms of form the reticuloendothelial system and circulate in the vessels of the lymphatic system. Traditionally, Lymphoma is classified lymphoma cancer as Hodgkin's lymphoma, disc...

วารสารโลหติวทิยาและเวชศาสตร บรกิารโลหติ ป ที ่12 ฉบบัที ่4 ตลุาคม-ธนัวาคม 2545 must be considered in the differential diagnosis of an anterior mediastinal mass.1 The majority of mediastinal masses in this age group are malignant, mostly Hodgkins and NonHodgkins lymphoma.2 Less than 5% of mediastinal masses are of thymic origin. We report Case Report Massive Thymic Hyperplasia Mimicking Lymphoma:...

The pharmacokinetics of cyclophosphamide was studied in 10 Kenyan Africans with Hodgkins lymphoma. The mean +/- s.d. elimination half-life (t1/2) was 7.5 +/- 1.38 h. The mean +/- s.d. volume of the central compartment (V1) was 0.35 +/- 0.12 l/kg and the apparent volume of distribution (V) was 0.64 +/- 0.06 l/kg. The microconstants k21, k12 and k10 were 1.81 +/- 0.84 h-1, 1.90 +/- 1.080 h-1 and ...

background and objectives: classic hodgkin lymphoma (chl), anaplastic large cell lymphoma (alcl) and some cases of diffuse large b cell lymphoma (dlbcl) have overlapping morphologic features. since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them. materials and methods: we included 61 cases ...

We report a rare case of Primary Non-Hodgkins lymphoma of prostate presenting as an emergency with gross haematuria. A review of literature is also discussed. A 71 year old man presented to Emergency department with gross haematuria and was found to have grossly enlarged right lobe of the prostate on digital rectal examination. Histology confirmed a diffuse large B-cell lymphoma of the prostate...