Ethanol potentiates glycinergic synaptic transmission to hypoglossal motoneurons (HMs). This effect on glycinergic transmission changes with postnatal development in that juvenile HMs (P9-13) are more sensitive to ethanol than neonate HMs (P1-3). We have now extended our previous study to investigate ethanol modulation of synaptic GABA(A) receptors (GABA(A)Rs), because both GABA and glycine med...

Heterochromatin underpins gene repression, genome integrity, and chromosome segregation. In the fission yeast Schizosaccharomyces pombe, conserved protein complexes effect heterochromatin formation via RNA interference-mediated recruitment of a histone H3 lysine 9 methyltransferase to cognate chromatin regions. To identify small molecules that inhibit heterochromatin formation, we performed an ...

Hydrological modeling is a widely used approach for estimating the hydrological response of basin to precipitation. Floods are among most catastrophic natural disasters in small urban watersheds, inflicting loss life, massive property destruction, and severe danger economy. As result, appropriate can be useful tool preventing mitigating such flood hazards. Despite this, flash prediction remains...

Heavy metals (HMs) are common components of landfill leachates and piggery wastewater, which correspond with possible applications of the anaerobic ammonium oxidation (anammox). For this reason, the study of the fate and effect of HMs on the anammox process is of utmost importance. In this work, the effect of several HMs on the specific anammox activity (SAA) was studied. For this purpose, the ...

This study aimed to predict the optimal carbon source for higher production of exopolysaccharides (EPS) by Lactobacillus paracasei TD 062, and evaluate effect this on monosaccharide composition EPS. We evaluated EPS capacity 20 strains L. under same conditions. further investigated which showed highest EPS-producing activity (0.609 g/L), examining associated biosynthesis pathways Genomics revea...

OBJECTIVE Hazmat disaster preparedness is critical, especially as Hong Kong prepares for major international events, such as the 2008 Olympic Equestrian Games. No published medical study describes the identities and quantities of hazardous materials (HMs) in Hong Kong and lists what antidotes are needed for these dangerous goods (DGs). This study describes what HMs are most common in Hong Kong ...

BACKGROUND Patients with atopic dermatitis (AD) exhibit various symptoms, especially itching. Recently, herbal medicines (HMs) are being used in combination with antihistamines for the treatment of AD in Korea. While oral antihistamines can alleviate itching, HMs appear to exert anti-inflammatory effects with minimal side effects. However, there is little evidence regarding the effectiveness an...

Early life events influence vulnerability to psychiatric illness. This has been modelled in rats and it has been demonstrated that different durations of maternal separation shape adult endocrine and behavioural stress reactivity. One system through which maternal separation may act is the locus coeruleus (LC)-norepinephrine system that regulates emotional arousal. Here we demonstrate that diff...

The red blood cell hexose monophosphate shunt (HMS) and proteolytic responses to several concentrations of Methylene Blue or sodium nitrite were measured. The results suggested two distinct mechanisms for activation of the HMS: (1) nitrite treatment increased HMS activity in response to oxidative challenge to red cell protein; (2) Methylene Blue treatment activated HMS without injurious oxidati...