Regulation of gene expression requires both transcription factor (TFs) and epigenetic modifications, and interplays between the two types of factors have been discovered. However study of relationships between chromatin features and TF-TF co-occupancy remains limited. Here, we revealed the relationship by first illustrating distinct profile patterns of chromatin features related to different bi...

Task reassignments in 2D mesh-connected systems (2D-MSs) have been researched for several decades. We propose a hierarchical 2D mesh-connected system (2D-HMS) in order to exploit the regular nature of a 2D-MS. In our approach priority-based task assignments and reassignments in a 2D-HMS are represented by tableaux and their algorithms. We show how task relocations for a priority-based task reas...

Haim Munk Syndrome (HMS) is the allelic mutation of exon 6 codon in cathepsin C gene. Here, we present two cases of same family with HMS having all the cardinal features of HMS which includes palmo plantar keratoderma and periodontitis along with arachnodactyly, acroosteolysis, onychogryphosis, and marked osteopenia on hand wrist radiographs. Both the siblings were treated with cotrimoxazole, a...

This paper presents a model of fault-tolerant Holonic Manufacturing Systems (HMS), where each holon is a knowledge-based agent capable of solving distributed problems by applying production/assembly and information management services. Our multi-agent architecture provides robustness and distribution transparency within a shop-floor environment where unpredictable failures occur with machines, ...

Recently, an extension to standard hidden Markov models for speech recognition called Hidden Model Sequence (HMS) modelling was introduced. In this approach the relationship between phones used in a pronunciation dictionary and the HMMs used to model these in context is assumed to be stochastic. One important feature of the HMS framework is the ability to handle arbitrary model to phone sequenc...

Three different water-alcohol cosolvent systems were used to assemble mesoporous molecular sieve silicas with wormhole framework structures (previously denoted HMS silicas) from an electrically neutral amine surfactant (S°) and a silicon alkoxide precursor (I°). The fundamental particle size and associated textural (interparticle) porosity of the disordered structures were correlated with the s...

Insulin-like growth factors (IGFs) are important regulators of the activity of mature osteoblasts, but their effects on osteoprogenitor cells in human bone marrow stroma are unclear. In this study, we assessed the effects of IGFs on a conditionally immortalized human marrow stromal cell line, hMS(3-4), which has the ability to differentiate to either mature osteoblasts or adipocytes. hMS(3-4) c...

UNLABELLED BACKGROUND The aim of the paper is to assess by the principal components analysis (PCA) the heavy metal contamination of soil and vegetables widely used as food for people who live in areas contaminated by heavy metals (HMs) due to long-lasting mining activities. This chemometric technique allowed us to select the best model for determining the risk of HMs on the food chain as wel...

Various analytical technologies have been developed for quantitative determination of marker compounds in herbal medicines (HMs). One important issue is matrix effects that must be addressed in method validation for different detections. Unlike biological fluids, blank matrix samples for calibration are usually unavailable for HMs. In this work, practical approaches for minimizing matrix effect...

OBJECTIVE The objective is the investigation of Joint Hypermobility (JH) and the Hypermobility Syndrome (HMS) in patients with inflammatory bowel disease (IBD). METHODS We examined 83 patients with IBD and 67 healthy individuals for the presence of JH. Patients were excluded if they were under 18 or over 50 years of age and if they had other conditions which affect joint mobility. The x(2) an...