نتایج جستجو برای: hla dq2
تعداد نتایج: 40118 فیلتر نتایج به سال:
We here describe that soluble HLA-DQ2 (sDQ2)molecules, when expressed in Drosophila melanogaster S2insect cells without a covalently tethered peptide, associatetightly with the D. melanogaster calcium binding proteinDCB-45. The interaction between the proteins is stable in S2cell culture and during affinity purification, which is done athigh salt concentrations and pH 11...
BACKGROUND Evaluation of intraepithelial duodenal lymphocytosis (IDL) is important in celiac disease (CD). There is no established cut-off value for increased number of IELs in the bulb.We therefore investigated the relation between IEL counts in the bulb and duodenal specimens in non-celiac subjects. METHODS The number of CD3+ IELs was determined in specimens from the second part of the duod...
Dermatitis herpetiformis (DH) shares some clinical features and major histocompatibility complex (MHC) markers with gluten-sensitive enteropathy (GSE). We compared MHC haplotypes in 27 patients with DH, 35 patients with GSE, and normal controls. As in GSE, the frequencies of two extended haplotypes, [HLA-B8, SC01, DR3] and [HLA-B44, FC31, DR7], were increased in patients with DH. Distributions ...
espite its heterogeneous clinical appearance, coeliac disease has a remarkable uniform human leuco-cyte antigen (HLA) association. The majority of coeliac disease patients carry a certain variant of HLA-DQ2, the rest carry HLA-DQ8. 1 2 As the physiological role of the HLA system is to present pep-tide fragments of antigens to T cells, it would seem logical that the HLA-DQ2 and HLA-DQ8 molecules...
BACKGROUND Human leukocyte antigens (HLA) complex and INS-IGF2 5'VNTR loci are principal determinants of the risk of type 1 diabetes mellitus (T1DM). Carriage of class III allele is protective, while class I/I homozygosity increases the risk of T1DM. MATERIAL AND METHODS HLA and 5'VNTR allele frequencies were summarised and multivariate logistic regression models with interaction evaluation w...
Celiac disease is a human leukocyte antigen (HLA)-DQ2- and/or DQ8-associated T cell-mediated disorder that is induced by dietary gluten. Although it is established how gluten peptides bind HLA-DQ8 and HLA-DQ2, it is unclear how such peptide-HLA complexes are engaged by the T cell receptor (TCR), a recognition event that triggers disease pathology. We show that biased TCR usage (TRBV9(∗)01) unde...
سابقه و هدف: از عوامل ژنتیکی مهم در ابتلا به بیماری سیلیاک، حضور الل های hla-dq2 و hla-dq8 در افراد مبتلا می باشد. روش های مولکولی زیادی جهت تعیین این الل ها در دسترس می باشد اما این روش ها علاوه بر هزینه بالا، دارای مراحل متعددی هستند که استفاده از آن ها را دشوار کرده است، لذا هدف از این مطالعه، راه اندازی تکنیک ساده و سریع جهت تعیین الل های hla-dq در بیماران مبتلا به سیلیاک با روش sybr g reen...
Gluten-specific T cells in the small intestinal mucosa are thought to play a central role in the pathogenesis of celiac disease (CD). The vast majority of these T cells recognize gluten peptides when presented by HLA-DQ2 (DQA1*05/DQB1*02), a molecule which immunogenetic studies have identified as conferring susceptibility to CD. We have previously identified and characterized three DQ2-restrict...
The oral thrombin inhibitor ximelagatran was withdrawn in the late clinical trial phase because it adversely affected the liver. In approximately 8% of treated patients, drug-induced liver injury (DILI) was expressed as transient alanine transaminase (ALT) elevations. No evidence of DILI had been revealed in the pre-clinical in vivo studies. A whole genome scan study performed on the clinical s...
The purpose of this study was to evaluate the association between the frequencies of DR and DQ HLA class II alleles and the prevalence of dental caries in Brazilian adolescents. The study sample consisted of 164 adolescents aged 15- 19 years. For the assessment of caries experience the DMFT index was used, according to World Health Organization criteria. DNA samples of the adolescents were extr...
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