Background There is an ongoing debate whether patients with constitutional varus should be restored to neutral mechanical alignment following total knee arthroplasty (TKA). Objective The aim of this retrospective cohort study is to determine whether mild unintentional postoperative varus alignment (3°-6°) influences TKA outcome in patients with and without preoperative varus alignment due to ...

BACKGROUND Varus deformity increases the risk of progression of medial compartment knee osteoarthritis. The aim of this study was to investigate the clinical and radiographic mid-term results of closing-wedge and opening-wedge high tibial osteotomy when used to treat this condition. METHODS From January 2001 to April 2004, ninety-two patients were randomized to receive either a closing-wedge ...

Signatures of balancing selection operating on specific gene loci in endemic pathogens can identify candidate targets of naturally acquired immunity. In malaria parasites, several leading vaccine candidates convincingly show such signatures when subjected to several tests of neutrality, but the discovery of new targets affected by selection to a similar extent has been slow. A small minority of...

BACKGROUND Although constrained condylar knee (CCK) inserts are widely used for total knee arthroplasty (TKA), their long-term outcomes remain unclear. We sought to evaluate patients with at least 10 years' follow-up after CCK TKA to identify potential adverse events (osteolysis, loosening, constraint-mechanism failure), assess functional outcomes with special emphasis on range of motion, and d...

Fishes are equipped to sense stressful stimuli and are able to respond to environmental stressor such as hypoxia with varying pattern of stress response. The functional attributes of brain to hypoxia stress in relation to ion transport and its interaction during immune challenge have not yet delineated in fish. We, therefore, explored the pattern of ion transporter functions and messenger RNA (...

INTRODUCTION Treatment of medial tibiofemoral osteoarthritis with a high-tibial osteotomy (HTO) is most effective when the optimal angular correction is achieved. However, conventional instrumentation is limited when multiplanar correction is needed. HYPOTHESIS Use of patient-specific cutting guides (PSCGs) for HTO provides an accurate correction (difference<2°) relative to the preoperative p...

objectives: this paper describes further improvement and preliminarily evaluation of a novel viscoelastic ankle-foot prosthesis prototype. the objective was to control the ankle hysteresis at slow and normal walking speeds. methods: inspired by the ankle biomechanics, in which the hysteresis differs based on the gait speeds, a manually damping control mechanism imbedded in the prosthesis for ad...

: investigating the mechanical behaviour of a healthy human ankle shows that it can be simulated by a mechanism composed of simple elements such as spring, and actuator. hence, appropriate design of this mechanism can be resulted to an artificial ankle that can help amputees properly. researches show that whatever the biomechanical behaviour of artificial ankle is similar to that of natural ank...

ankle sprains are among the most common injuries in athletes and military recruits. high bmi, previous history of ankle sprain, poor muscle strength, proprioceptive deficits, limitation in rom and balance are important risk factors for ankle sprain. recent studies have shown that external support such as brace and tape significantly reduces the risk of primary and recurrent ankle sprains in ath...

We performed a comparative study of the short-term radiological and clinical results after implantation of an unconstrained TKA with preservation of the posterior cruciate ligament with a conventional (50 cases--group A) or navigated (50 cases--group B) technique. The primary criterion was the postoperative leg coronal alignment measured on 3-month postoperative anteroposterior long-leg radiogr...