نتایج جستجو برای: hiv i
تعداد نتایج: 1238862 فیلتر نتایج به سال:
Background Disease progression is rapid in human immunodeficiency virus (HIV)-infected infants. Whether intestinal damage and inflammation underlie mortality is unknown. Methods We measured plasma intestinal fatty acid binding protein (I-FABP), soluble CD14 (sCD14), interleukin 6 (IL-6), and C-reactive protein (CRP) at 6 weeks and 6 months of age in 272 HIV-infected infants who either died (c...
It is believed that Nef-mediated HLA class I down-regulation is one of the mechanisms that allow HIV-1-infected cells to escape from being killed by HIV-1-specific human CTLs. In this study, we show that the effect of Nef-mediated HLA class I down-regulation on the ability of HIV-1-specific CTLs to suppress HIV-1 replication is epitope dependent. The CTLs specific for two Pol epitopes presented...
OBJECTIVE The human APOBEC3 family of proteins potently restricts HIV-1 replication APOBEC3B, one of the family genes, is frequently deleted in human populations. Two previous studies reached inconsistent conclusions regarding the effects of APOBEC3B loss on HIV-1 acquisition and pathogenesis. Therefore, it was necessary to verify the effects of APOBEC3B on HIV-1 infection in vivo. METHODS In...
Mechanisms underlying HIV-1 latency remain among the most crucial questions that need to be answered to adopt strategies for purging the latent viral reservoirs. Here we show that HIV-1 accessory protein Vpr induces depletion of class I HDACs, including HDAC1, 2, 3, and 8, to overcome latency in macrophages. We found that Vpr binds and depletes chromatin-associated class I HDACs through a VprBP...
Although HIV type 1 (HIV-1) cannot efficiently replicate in simian cells, the mechanism(s) involved in the restriction of virus tropism remain unclear. To investigate this, we have focused on the identification of human cellular factors that can influence the infectivity of HIV-1 derived from African green monkey producer cells. Whereas the infectivity of HIV-1 derived from such cells was only ...
A puzzle in HIV prevention is that while HIV tests provide important information about a person's health status, it has little e ect on risky sexual behavior. One explanation is that testing only a ects people if it provides new information about their HIV status. Using data from a study that randomly assigns o ers of HIV testing in two urban centers in East Africa, I examine the e ects of test...
Recent reports have indicated that China, India and Russia are headed for a major public health calamity with regard to AIDS if indeed the calamity is not already upon these countries. It is therefore of some concern that there is uncertainty associated with existing estimates of the number of HIV infected individuals in India. According to a report, the US Central Intelligence Agency has predi...
<b><i>Introduction:</i></b> Portugal is one of the countries in Western Europe with highest prevalence tuberculosis (TB) and human immunodeficiency virus (HIV). The among migrants estimated to be higher than non-migrants, which suggests a greater vulnerability this population. <b><i>Aim:</i></b> To describe distribution TB, HIV HIV-TB co-infection...
Type-I interferon (IFN-I) has been increasingly implicated in HIV-1 pathogenesis. Various studies have shown elevated IFN-I and an IFN-I-induced gene and protein expression signature in HIV-1 infection, yet the elevated IFN-I species has not been conclusively identified, its source remains obscure and its role in driving HIV-1 pathogenesis is controversial. We assessed IFN-I species in plasma b...
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