A radiographic and histomorphometric study was conducted on the influence of autologous plasma rich in growth factors (PRGF) upon bone healing in surgically created defects in rabbits. Radiographically, bone regeneration was significantly greater with the use of PRGF after one month (p = 0.005), though no differences were recorded after the second month. In the histomorphometric analysis one mo...

Using standard histomorphometric indices on bone biopsies of trabecular bone volume, osteoid volume, the trabecular osteoid surface, the extent of the calcification front and the number of osteoid lamellae, a histomorphometric diagnosis of osteomalacia was made in three of 28 elderly female patients with fracture of the proximal femur. These patients also showed biochemical changes in the serum...

PURPOSE Surgery of irradiated tissue has an increased complication rate because of the development of hypovascular, hypocellular, and hypoxic tissue. This study was undertaken to perform histopathologic and histomorphometric analyses of irradiation tissue injury in bone and the surrounding soft tissues. MATERIAL AND METHODS The histopathologic findings of 40 human mandibular bones and the sur...

Tetracyclines are considered potential medication for the treatment of osteoporosis. The aim of the present study was to investigate the effects of doxycycline on development of unfavorable changes in bone histomorphometric parameters induced by bilateral ovariectomy in rats. Doxycycline at a dose of 20 mg/kg po daily was administered for 28 days to bilaterally ovariectomized and sham-operated ...

Bone specimens were obtained from four different sites in the ilium of necropsy cases using a Jamshidi 8G trephine needle. Undecalcified histological sections were prepared and two structural histomorphometric parameters were estimated. Estimates of the percentage of trabecular bone volume (%TBV) deviated systematically, with variation of the biopsy site around the usual location, increasing in...

Methyl tertiary-butyl ether (MTBE) is used to reduce carbon monoxide and ozone in urban air and to boost fuel octane. There is a lack of knowledge in the literature about the histomorphometric changes of the testis following exposure to MTBE. Therefore, this experimental study was performed to determine the effect of oral exposure to MTBE on histologic and histomorphometric changes of testis in...

Objective: The aim of this study was to assess, through biological analysis, the local effects and osseointegration dental implants incorporating surface micro/nanofeatures compared identical design without treatment. Background: Known impact bone cell behavior, chemical topography modifications target improved long-term success implants. Very few studies assess performance presenting both micr...

This study presents a histomorphometric and biomechanical comparison of bone response to commercially pure titanium screws with 4 different types of surface topographies placed in the tibial metaphysis of 12 rabbits. Each rabbit had 4 implants placed, 2 in each tibia. The 4 surface topographies were a machined surface, a grit-blasted surface, a plasma-sprayed surface, and an acid-etched (Osseot...

Bone histomorphometry is a quantitative histological examination of an undecalcified bone biopsy performed to obtain quantitative information on bone remodeling and structure. Labeling agents taken before the procedure deposit at sites of bone formation allowing a dynamic analysis. Biopsy is indicated to make the diagnosis of subclinical osteomalacia, to characterize the different forms of rena...

Histomorphometric analysis was performed on transiliac undecalcified bone biopsies taken from eight adults and four children with osteogenesis imperfecta. Double tetracycline labelling done before the biopsy allowed measurement of the calcification rate in 11 patients. The adults, as well as the children, had thin iliac cortices and considerably decreased trabecular bone volume. In addition, th...