Penile erection is dependent on the nitric oxide (NO)/cGMP-dependent protein kinase I (PKGI) pathway. One important target of PKGI in smooth muscle is the large-conductance, calcium-activated potassium (BK) channel, which upon activation hyperpolarizes the smooth muscle cell membrane, causing relaxation. Relaxation of arterial and corpus cavernosum smooth muscle (CCSM) is necessary to increase ...

To clarify the optimal timing of second look operation (SLO) for advanced ovarian cancer, we retrospectively reviewed the records of 53 patients with FIGO stage 2, 3 and 4 epithelial ovarian cancer. SLOs were performed more than 12 months after primary surgery in 35 patients (late SLOs), and immediately after first-line chemotherapy in 18 patients (early SLOs). We examined data on SLO findings ...

Positioning service is one of Wireless Sensor Networks’ (WSNs) fundamental services. The accurate position of the sensor nodes plays a vital role in many applications of WSNs. In this paper, a 3D positioning algorithm is being proposed, using mobile anchor node to assist sensor nodes in order to estimate their positions in a 3D geospatial environment. However, mobile anchor node’s 3D path optim...

Large conductance (BK) calcium activated potassium channels (Slo) are ubiquitous and implicated in a number of human diseases including hypertension and epilepsy. BK channels consist of a pore forming α-subunit (Slo) and a number of accessory subunits. In hair cells of nonmammalian vertebrates these channels play a critical role in electrical resonance, a mechanism of frequency selectivity. Hai...

the capacitated vehicle routing problem (cvrp) is a well-known combinatorial optimization problem that holds a central place in logistics management. the vehicle routing is an applied task in the industrial transportation for which an optimal solution will lead us to better services, save more time and ultimately increase in customer satisfaction. this problem is classified into np-hard problem...

BACKGROUND The large conductance calcium-activated potassium channel alpha-subunit (Slo) is widely distributed throughout the body and plays an important role in a number of diseases. Prior work has shown that Slo, through its S10 region, interacts with β-catenin, a key component of the cytoskeleton framework and the Wnt signaling pathway. However, the physiological significance of this interac...