A series of twelve recently synthesized 6-substituted derivatives of 9-beta-d-ribofuranosylpurine 3',5'-cyclic phosphate (RPcMP) were evaluated for in vitro antiviral activity, using inhibition of viral cytopathogenic effect as the primary parameter for evaluation. Inhibition of the development of intra- and extracellular virus titer was used as a secondary criterion with certain viruses. Five ...

Background: Herpes simplex virus (HSV) encephalitis is the most common cause of sporadic encephalitis, with significant morbidity and mortality that are effectively reduced by antiviral treatment. Herpes simplex infection in pregnant women rarely results in encephalitis. The most common symptoms of a pregnant woman with herpes simplex infection are colds and skin vesicles. Herpetic encephalitis...

The triphosphate form of the acyclovir analog BW759U (9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine) inhibited the DNA polymerases (EC 2.7.7.7) from several strains of herpes simplex virus type 1. Two acyclovir triphosphate-resistant DNA polymerases were as sensitive to BW759U-triphosphate as were the DNA polymerases induced by wild-type viruses (Ki = 0.05 to 0.1 microM). The Ki value fo...

Benencia, F. (1999). Antiviral activity of sandalwood oil against Herpes simplex viruses-1 and -2. Phytomedicine 6(2), 119-23. The study tested the antiviral activity of sandalwood oil, the essential oil of Santalum album L against Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2). Results demonstrated dose-dependent effect of sandalwood oil in inhibiting the replication of virus, and more sign...

Purified herpes simplex virus thymidine kinase has been used to immunize mice for the production of monoclonal antibodies to the enzyme. Monoclonal antibodies were successfully produced against both herpes simplex virus type 1 and type 2 enzymes. These antibodies should prove useful for detecting the enzyme under a variety of experimental conditions. We also demonstrate that the antibodies can ...

Inhibitors of cell enzyme Inosine 5 ́-Monophosphate (IMP) dehydrogenase – Ribavirine (Rbv), Micophenolic acid (MPA) and Mizoribine (MZR) have potential application as antiherpes agents in combination with acyclovir (ACV). The effectivity of action of ACV on herpesvirus replication is improved after decreasing of the concentration of dGTP as a result of IMP dehydrogenase inhibition. The antiviral...