5-IoDo-2'-DEOXYURIDINE (IDU) is an antimetabolite that acts by displacing thymidine from deoxyribonucleic acid (DNA). This results in inhibition of DNA synthesis, which particularly affects virus particles in the active replication of herpes simplex keratitis in rabbits (Kaufman, Nesburn, and Maloney, 1962; Perkins, Wood, Sears, Prusoff, and Welch, 1962). Following the report of effective treat...

A case of posterior corneal abscess with extension into the anterior chamber, in the presence of an intact corneal epithelium and clear anterior corneal stroma, occurring in a young patient is described. The patient responded to treatment with systemic and topical acyclovir. The diagnosis of presumed herpes simplex keratitis was made. We report this unusual presentation of ocular herpes manifes...

PURPOSE To evaluate the leading indications for penetrating keratoplasty (PKP) and their trends in Greece during the period 1982 to 2006. METHODS Retrospective data review of 1,929 patients (2233 eyes) who underwent PKP in the period between 1982 and 2006 at three cornea transplantation units of three hospitals in Greece (Athens General Hospital, Heraklion University Hospital of Crete, and Th...

PURPOSE To report the outcomes of laser in situ keratomileusis (LASIK) in patients with a history of ocular herpes simplex virus (HSV) or herpes zoster ophthalmicus (HZO). SETTING Clínica Baviera, Instituto Oftalmológico Europeo, Madrid, Spain. METHODS In this retrospective case series, the records of eyes with a history of ocular herpes that had LASIK from 2003 through 2005 were reviewed. ...

PURPOSE Herpes simplex virus type I (HSV-1) is capable of causing a wide array of human ocular diseases. Herpes simplex virus keratitis (HSK)-induced cytopathogenicity together with the chronic immune-inflammatory reaction can trigger stromal scarring, thinning, and neovascularization which may lead to permanent vision impairment. Lychee flower extract (LFE) is known for its antioxidant and ant...

Purpose To describe three cases of keratitis following Selective Laser Trabeculoplasty (SLT). Observations Three females with a history of glaucoma presented with corneal edema, keratitis (endothelial, epithelial) and decreased visual acuity shortly after SLT. There was variable resolution of symptoms after starting treatment with oral antiherpetics and topical steroids. Conclusions and imp...