Matrix metalloproteinases (MMPs) play vital roles in many pathological conditions, including cancer, cardiovascular disease, arthritis and inflammation. Modulating MMP activity may therefore be a useful therapeutic approach in treating these diseases. Qing-Kai-Ling is a popular Chinese anti-inflammatory formulation used to treat symptoms such as rheumatoid arthritis, acute hypertensive cerebral...

Neurodegeneration refers to a condition of neuronal death occurring as a result of progressive disease of long term. It involves degeneration of circumscribed group of neurons that may be functionally or neuroanatomically connected. Parkinson’s disease (PD) is a chronic, progressive neurological disorder. Recent studies have indicated that a part of active compounds extracted from herbal medici...

Terminalia arjuna, Centella asiatica and Curcuma longa are reported to possess wound healing, anti-inflammatory, antioxidant and anti-bacterial activities. The carbopol 934 gel formulations containing different concentrations of extract of the above mentioned herbs were formulated and their wound healing activity was studied on experimentally induced open wounds in albino rats. The individual h...

The aim of this study is to investigate the effects of Panax quinquefolius L. extract (PQE), Ginkgo biloba extract (GBE), and Hypericum perforatum extract (HPE), in combination or alone, on the survival and regeneration of axotomized retinal ganglion cells (RGCs) in an optic nerve transection model in adult hamsters. Unilateral transection of the optic nerve was performed to evaluate the effect...

Objective: In recent years, there has been an increasing interest in using herbal products to overcome bacterial resistance. The aim of this study was to investigate the effect of lemon verbena aqueous extract, verbascoside and caffeine in combination with gentamicin against standard and clinical isolates of Staphylococcus aureus and Escherichia coli strains. Materials and Methods: The MIC and ...

BACKGROUND Obesity and overweight are consistently associated with metabolic disorders including hyperglycemia and hyperlipidemia. Herbal medicines have been currently suggested as an alternative source of potentially useful antihyperglycemic, antihyperlipidemic, antioxidant activities. The objective of this study was to assess the in vitro inhibitory effects of eleven herbal medicines on carbo...

Screening of herbal remedies for Cl(-) channel inhibition identified Krisanaklan, a herbal extract used in Thailand for treatment of diarrhea, as an effective antidiarrheal in mouse models of secretory diarrheas with inhibition activity against three Cl(-) channel targets. Krisanaklan fully inhibited cholera toxin-induced intestinal fluid secretion in a closed-loop mouse model with ∼50% inhibit...

Chemical and physical quality attributes of herbal extract powders play an important role in the research and development of Chinese medicine preparations. The active pharmaceutical ingredients have a direct impact on the herbal extract's efficacy, while the physical properties of raw material affect the pharmaceutical manufacturing process and the final products' quality. In this study, tanshi...

BACKGROUND AND OBJECTIVES Herbal medicines have good curative effect on certain diseases especially for diabetes mellitus which needs continuous medication throughout the life. Present day allopathic medicines are costlier and having more side effects which could cause severe damages to the vital organs. Hence, finding a suitable herbal medicine for diabetes mellitus is very important in the cu...

BACKGROUND The aim of this study was to evaluate the antimalarial effects of Iranian flora Artemisia khorassanica against Plasmodium bergheiin vivo and pharmacochemistry of its natural components. METHODS The aerial parts of Iranian flora A. khorasanica were collected at flowering stage from Khorassan Province, northeastern Iran in 2008. They were air-dried at room temperature; powder was mac...