Hepatoblastomas among children with very low birth weights have significantly increased recently, according to the data from the Japan Children's Cancer Registry for the years 1985-1993. We then analyzed more Registry data for 1969-1994 to clarify the possible relationship between low birth weight and hepatoblastoma. The percentage of low birth weights was compared between 543 hepatoblastoma ch...

Background: In the past 20 years, a dramatic improvement in the prognosis of patients with hepatoblastoma (HB)has been achieved by combining surgery and chemotherapy in several national and international trials.Materials and Methods: Four children ( 3 girl and 1 boy) aged 34 days, 4 months, 13 months, and 1 year with meanage of 6.53 (±5.15) months were presented to our center from 2002 to 2009 ...

Background and Aim: Alagille syndrome (AGS) is a rare multisystem genetic disorder of autosomal dominant inheritance classically characterized by intrahepatic bile duct paucity in conjunction with various combinations extrahepatic manifestations characteristic facial features. Apart from hepatic these patients are also at risk developing wide variety liver tumours including nodular hyperplasia ...

We report a case of a 18-year-old boy who presented with dyspnea and right upper quadrant abdominal dull pain. According to urgent echocardiography, a dense sessile mass occupied the right ventricule. Tumor resection was performed, followed by further adjuvant therapy. The specimen was histopathologically investigated and eventually diagnosed as metastatic adult hepatoblastoma. We discuss its c...

Hepatoblastoma is the most frequent primary liver tumor of childhood, with an annual incidence of 0.5-1.5 cases per million (1). It is very rare in adults, with a controversial existent since some authors believe that most of them are really underdiagnosed hepatocarcinomas, mixed sarcomas or hepatic cholangio-hepatocarcinomas. To date, there are only 40 reported cases of hepatoblastoma in adult...

Of 825 pediatric malignancies diagnosed at our institution between 2005 and 2012, 13 (1.6%) had primary liver tumors. The median age was 4 years (2 mo 15 yrs), 9 males. In 12 cases (92.3%), a malignant primary was present of which hepatoblastoma was the commonest, seen in 8(67%) cases. Hepatocellular carcinoma (HCC) was diagnosed in 3(25%) and undifferentiated embryonal sarcoma(UES) in 1(8%). M...