OBJECTIVES Oxytetracycline (OTC) is a broad spectrum antibiotic widely used for treatment of a wide range of infections. However, its improper human and animal use leads to toxic effects, including hepatonephrotoxicity. Our objective was to evaluate protective effects of Nigella sativa oil (NSO) and/or ascorbic acid (AA), against OTC-induced hepatonephrotoxicity in rabbits. MATERIALS AND METH...

Hepato-renal syndrome (HRS) is a rare complication that may accompany end-stage cystic fibrosis-associated cirrhosis in patients with fibrosis. There currently no unified protocol for the diagnosis and treatment of HRS fibrosis, particularly pediatric patients. The main approaches to diagnosing condition are detect signs acute renal failure patient severe liver damage absence shock organic kidn...

Introduction: Medicinal plants such as Cnidoscolus aconitifolius (CA) have been studied over the years for their protective and curative potentials against a myriad of common global health challenges hepatorenal injuries.
 Objectives: To ascertaining effects hydromethanol leaf extract CA (HMLECA) on hepato-renal parameters in adult male wistar rats.
 Method: A total 18 rats were divid...

Lead is a non-biodegradable multi-organ toxicant implicated in various disorders including renal and hepatic diseases. In the quest for cheaper readily available antidote, this study has investigated role of Solanum anomalum fruit extract lead-induced kidney liver toxicities male albino rats. Twenty-four mature rats were used, divided into four groups six per group. Group 1 (control rats) recei...

INTRODUCTION Circulatory dysfunction in cirrhotic patients may cause a specific kind of functional renal failure termed hepato-renal syndrome (HRS). It contributes to the high incidence of renal failure in cirrhotic intensive care unit (ICU) patients. Fluid therapy may aggravate renal failure by increasing ascites and intra-abdominal pressure (IAP). This study investigates the short-term effect...

Leptospirosis in humans is a common zoonotic disease. It is often under-diagnosed, especially when associated with neurological features, resulting in significant morbidity and mortality. This subgroup of patients with neurological manifestations is often empirically treated for cerebral malaria, dengue fever, tuberculous meningitis, hepatic encephalopathy, viral encephalitis, etc. Hence it is ...

Objective(s): This study aimed to develop drugs from natural sources to overcome the side effects of many of synthetic drugs. Methanol extracts of both pericarp and seeds of Pleiogynium solandri were used to investigate antioxidant, hepatoprotective, and renal function protective, analgesic, and anti-inflammatory effects and to determine the chemical composition of the extract responsible for b...

Prone positioning may even in patients without abdominal hypertension result in an increased intra-abdominal pressure (IAP). Previous research could not demonstrate a marked increase in IAP associated with cardiovascular, renal, or hepato-splanchnic dysfunction when patients were proned in air-cushioned beds. Michelet and colleagues in this issue of Critical Care report that the increase in IAP...

We describe a 77-year-old man with diabetes mellitus who developed a large gas-containing pyogenic liver abscess after admission. Mild elevation of serum biliary enzyme levels suggested probable biliary trouble on admission. Ultrasonography and computed tomography showed a large abscess of the liver with gas formation and the presence of gas within the lumina of the gallbladder and biliary trac...