The modifying effect of partial hepatectomy and gonadectomy upon carcinogenesis in general and hepatocarcinogenesis in particular has been evaluated in 6-week-old C57BL/6J x C3HeB/FeJ F, mice. Ethylnitrosourea (60 ftg/g body weight) was administered once after sham hepatectomy or 48 hr following partial hepatectomy at which time DMA synthesis in the regenerating liver was 30-fold higher than in...

The factors controlling the initiation, maintenance, and ces sation of hepatic cell mitosis in response to partial hepatectomy are not completely understood. Evidence offered by parabiont studies favors considering the presence of a humoral factor (7, 10, 16). The present study demonstrates the effect of the postulated humoral factor upon tumor cells present in the liver during the 12-day perio...

Triiodothyronine administration before partial hepatectomy increased the activity of mitochondrial glycerophosphate cytochrome c reductase. The enzyme activity was further activated after partial hepatectomy during the regenerative process. Our findings showed that: a) the increase of glycerophosphate cytochrome c reductase induced by triiodothyronine was further potentiated by the regeneration...

The modifying effect of partial hepatectomy and gonadectomy upon carcinogenesis in general and hepatocarcinogenesis in particular has been evaluated in 6-week-old C57BL/6J x C3HeB/FeJ F, mice. Ethylnitrosourea (60 ftg/g body weight) was administered once after sham hepatectomy or 48 hr following partial hepatectomy at which time DMA synthesis in the regenerating liver was 30-fold higher than in...

OBJECTIVE To assess outcome after a 2-stage hepatectomy procedure (TSHP) combined with portal vein embolization (PVE) in the treatment of patients with unresectable multiple and bilobar colorectal liver metastases (MBCLM). BACKGROUND Patients with MBCLM are often considered for palliative chemotherapy only, due to too small future remnant liver (FRL). Recently, right hepatectomy with simultan...

The rise in hepatic DNA synthesis in response to partial hepatectomy was accelerated in rats subjected to surgery 4.5 to 8 hr or 3 days before hepatectomy. Bovine growth hor mone, in doses from 0.03 to 2.0 mg, also accelerated the response to hepatectomy, but cortisone, hydrocortisone, and adrenocorticotropic hormone were ineffective. Neither surgery nor growth hormone stimulated DNA synthesis ...

The rise in hepatic DNA synthesis in response to partial hepatectomy was accelerated in rats subjected to surgery 4.5 to 8 hr or 3 days before hepatectomy. Bovine growth hor mone, in doses from 0.03 to 2.0 mg, also accelerated the response to hepatectomy, but cortisone, hydrocortisone, and adrenocorticotropic hormone were ineffective. Neither surgery nor growth hormone stimulated DNA synthesis ...

Introduction: There are several controversies in the treatment strategy for multiple CRLM. Methods: Two hundred and fifty-eight patients underwent initial hepatectomy CRLM from 2001 to 2018. Clinicopathological data long-term outcomes were retrospectively analyzed. Results: MST 5-year OS 46 months 41.6%, which significantly worse compared that with solitary (Group S) (125 69.2%, p<0.001). R1 re...

For hepatocellular carcinoma (HCC) patients with macrovascular invasion (MaVI), hepatectomy and transcatheter arterial chemoembolization (TACE) remain the main treatment options in Asia. However, which could achieve better survivals remains controversial. In present study, we conducted a meta-analysis to clarify the survival benefits and safety of hepatectomy versus TACE in HCC patients with Ma...

BACKGROUND/AIMS To identify the clinical significance of the omental wrapping (OW) technique after left hepatectomy to reduce bile leakage and delayed gastric emptying. We examined clinical and surgical parameters after left hepatectomy with or without biliary reconstruction in 79 patients. METHODOLOGY This was a retrospective study of data from 14 patients undergoing OW compared to 65 patien...