BACKGROUND Necrosis of skin flaps is considered as an important complication in reconstructive surgery. We conducted an experimental study to investigate the efficacy of low-molecular weight heparin, clopidogrel and their combination to improve the flap survival. METHODS Forty male, adult Sprague-Dawlay rats were divided randomly into 4 groups. Standard rectangular, distally based dorsal ran...

OBJECTIVE To assess the effects of preoperative aspirin and/or intravenous heparin therapy on perioperative coagulation tests and postoperative blood loss for 24-hour after coronary artery bypass surgery. METHODS Multiple conventional coagulation tests, activated clotting time, thrombelastograph, skin bleeding time and platelet aggregation were performed before induction of anaesthesia, follo...

Adequate initial anticoagulant therapy of deep venous thrombosis (DVT) is required to prevent thrombus growth and pulmonary embolism (PE). Intravenous unfractionated heparin (UFH) is being replaced by low-molecular-weight heparin (LMWH) as the anticoagulant of choice for initial treatment of venous thromboembolism (VTE). Both agents are relatively safe and effective when used to treat VTE, with...

This article is also accessible online at: http://BioMedNet.com/karger Dear Sir, In a recent issue of Nephron Berlot and Lucchese [1] reported their management of heparin-associated thrombocytopenia (HAT) during continuous venovenous hemofiltration. They described a case of rapid onset of severe thrombocytopenia after initiating intravenous heparin therapy and stated ‘that the diagnostic criter...

a 25-year-old woman (gravida 2, abortion 1) was admitted to ghaem hospital affiliated to mashhad university of medical sciences at 24 th week of gestation. her chief complaint was bloody show. she had a history of incompetent cervix, with premature labor at 22 nd week of gestation. she was hospitalized with 4 cm dilatation and 50% effacement of cervix at 24 th week of gestation. following bed r...

Fig 1. Papules with overlying hemorrhagic crusting located on the proximal arm (underlying bruising is caused by recent trauma to the arm and is not a result of the patient’s hemorrhagic bullous dermatosis). INTRODUCTION Hemorrhagic bullous dermatosis is a rare, generalized skin reaction with unknown pathogenesis, described in association with heparin therapy. Heparin is known to cause injectio...