the olefins polymerization process in a slurry reactor is discussed. the reaction rate dynamics was analyzed and the contributions of feed flow, gas-liquid mass transfer, polymerization reaction, and catalyst deactivation were estimated. the propylene solubility in a solvent mixture “heptane” was calculated using soave-redlich-kwong equation of state. these data were then approximated by henry-...

A combinatorial in situ three-component chiral oxazoline-Schiff base copper(II) complex catalyst formation method was developed. This simple combinatorial chiral catalyst approach provided a modular library of chiral oxazoline-Schiff base copper(II) complex catalysts. The catalytic activity of these in situ generated catalysts can be rapidly and conveniently evaluated in the asymmetric Henry re...

A concise route for the synthesis of Fingolimod is reported. Starting from n-octylbenzene and 3-nitropropionic acid, a sequence of reactions consisting of Friedel-Crafts acylation, reduction, and double Henry reaction, followed by hydrogenation were applied to prepare Fingolimod with a yield of 31%, and an overall atom economy of 82.7%. Graphical AbstractStarting from 3-nitropropanyl chloride, ...

The vinylogous reactivity of α,β-disubstituted nitroolefins was uncovered through the facile generation of the corresponding α-substituted vinylogous nitronates and their use in the development of a highly diastereo- and enantioselective aza-Henry reaction with N-Boc aldimines under the catalysis of chiral ammonium betaines. The novel vinylogous nitronates undergo stereoselective bond formation...

at the age of 68, belonged to a family of surgeons. He was educated at the Bristol Royal Infirmary and Medical School, and very soon after qualifying he settled at Westbury. Although his capacity for work was immense, yet in the early years of his practice he had more than one attack of haemoptysis, and it was his opinion that leading a country open-air life had been the means of warding off mo...