The retinoblastoma (Rb) tumor suppressor plays important roles in regulating hematopoiesis, particularly erythropoiesis. In an effort to understand whether Rb function can be mediated by E2F transcription factors in a BM-derived hematopoietic system in mice, we uncovered a functional synergy between Rb and E2F8 to promote erythropoiesis and to prevent anemia. Specifically, whereas Mx1-Cre-media...

Iron deficiency is a common nutritional disorder worldwide and in our country, rarely associated with extreme thrombocytosis. It can also change laboratory values such as low hemoglobin, mean corpuscular volume (MCV). We describe here case of thrombocytosis healthy 4.5 year-old boy. He had reactive due to iron defiency anemia. ruled out other causes anemia hemolysis, infection, absorption probl...

BACKGROUNDS Hemolysis related to a kinked prosthetic graft or inner felt strip is a very rare complication after aortic surgery. We describe herein a case of hemolytic anemia that developed due to aortic flap of the dissection and inversion of an inner felt strip that was applied at the proximal anastomosis of a replaced ascending aorta 10 years previously. CASE PRESENTATION A 74-year-old wom...

It is widely accepted and clinically anticipated that the patient implanted with a mechanical circulatory assist device (MCAD) will develop a state of chronic anemia that will last throughout the duration of MCAD support. Large-scale hemolysis mediated by the high sheer stress transmitted to the erythrocytes (RBCs) from the mechanical action of most MCAD systems is the accustomed mechanism resp...

Anemia is one of the most characteristic and visable manifestations of chronic renal failure. Investigators in the past decade have provided a better understanding of this anemia. The etiology of the anemia of chronic renal failure has three facets: first is reduced erythropoietin production by damaged kidneys; second is the presence of inhibitors to red blood cell (RBC) production in uremic se...

Visceral leishmaniasis (VL) caused by the intracellular parasite Leishmania donovani accounts for an estimated 12 million cases of human infection. It is almost always associated with anemia, which severely complicates the disease course. However, the pathological processes leading to anemia in VL have thus far not been adequately characterized to date. In studying the glycosylation patterns of...

The hallmark of hemolysis is shortened red blood cell survival in the peripheral blood. Hemolysis results in anemia only when bone marrow cannot keep up with the rate of red cell destruction. Even though anemia is very commonly observed in most cancer patients, hemolytic anemias are rather rare. Acute or chronic hemolysis, when present can impact on quality of life adversely, especially when bo...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Autoimmune hemolytic anemia (AIHA) is an uncommon disorder characterized by hemolysis mediated by autoanti-bodies directed against self-red blood cells (RBC), with the incidence of 1–3 per 100,000/year and mortality rate of approximately 11% [1, 2]. AIHA is ...