Objective(s): High-risk neuroblastoma is a childhood cancer with poorprognosis despite modern multimodality therapy. Internal radiotherapy using131I-metaiodobenzylguanidine (MIBG) is effective for treating the disease even if it isresistant to chemotherapy. The aim of this study is to evaluate the safety and efficacyof 131I-MIBG radiotherapy combined with myeloablative high-dose chemotherapyand...

Hematopoietic stem-cell transplantation (HSCT) refers to a procedure in which hematopoietic stem cells are infused to restore bone marrow function in cancer patients who receive bone-marrowtoxic doses of cytotoxic drugs with or without whole-body radiation therapy. Bone marrow stem cells may be obtained from the transplant recipient (autologous HSCT) or from a donor (allogeneic HSCT). They can ...

background: umbilical cord blood (ucb) is an alternative source of hematopoietic stem cell transplantation (hsct), used in leukemia treatment. cd26+ cells, a fraction of cd34 positive cells, are a major population of ucb cells which negatively regulate the in vivo homing and engraftment of hscs. cd26 is highly expressed in various cells such as hscs, immune cells, fibroblasts, and epithelial ce...

Hematopoietic malignant relapse still remains the major cause of death following allogeneic hematopoietic stem cell transplantation (HSCT). Although there has been a large focus on the immunologic mechanisms responsible for the graft-versus-tumor (GVT) effect or lack thereof, there has been little attention paid to investigating the biologic basis of hematologic malignant disease relapse follow...

introduction: zinc (zn) deficiency can cause significant defects in cellular immunity. hematopoietic stem cell transplantation (hsct) patients usually experience serious deficiencies of all components of the immune system. therefore, the maintenance of a normal zn status may be important in this group of patients. patients and methods: serum zn levels were analyzed in 55 patients during the hsc...

Acute myeloid leukemia (AML) refers leukemias that arise from a myeloid precursor in the bone marrow. There is a high incidence of relapse, which has prompted research into various postremission strategies using either allogeneic (allo) or autologous hematopoietic stem cell transplantation (HSCT). HSCT refers to a procedure that infuses hematopoietic stem cells i to restore bone marrow function...

Acute myeloid leukemia (AML) refers to a set of leukemias that arise from a myeloid precursor in the bone marrow. There is a high incidence of relapse, which has prompted research into a variety of postremission strategies using either allogeneic or autologous hematopoietic stem cell transplantation (HSCT). HSCT refers to a procedure in which hematopoietic stem cells are infused to restore bone...

background: this study explored the state of hematopoietic stem cell transplantation (hsct) recipient patients and problems experienced by them and nurse about these state and problems, in iran. methods: qualitative content analysis was used for analyzing semi-structured interviews with 12 hsct recipient patients and 18 nurses. results: three main categories described the hsct state and problem...

Hematopoietic stem-cell transplantation refers to a procedure in which hematopoietic stem cells are infused to restore bone marrow function in cancer patients who receive bone-marrow-toxic doses of cytotoxic drugs with or without whole-body radiation therapy. Hematopoietic stem cells may be obtained from the transplant recipient (autologous HSCT) or from a donor (allogeneic HSCT). They can be h...

The globally widespread single-gene disorders β-thalassemia and sickle cell anemia (SCA) can only be cured by allogeneic hematopoietic stem cell transplantation (HSCT). HSCT treatment of thalassemia has substantially improved over the last two decades, with advancements in preventive strategies, control of transplant-related complications, and preparative regimens. A risk class-based transplant...