نتایج جستجو برای: hematopoietic
تعداد نتایج: 58242 فیلتر نتایج به سال:
The aim of this study was to isolate mouse embryonic stem cells from late blastocyst stage embryos and to use them as a model system for the study of hematopoietic induction outside the embryo by coculturing of embryonic stem cells with bone marrow stromal cells. Blastocyst stage embryos from pregnant NMRI mice were obtained and cultured for 1-2 days in DMEM medium. The inner cell masses formed...
Introduction: The features of a cell can be extracted from its gene expression profile. If the gene expression profiles of future descendant cells are predicted, the features of the future cells are also predicted. The objective of this study was to design an artificial neural network to predict gene expression profiles of descendant cells that will be generated by division/differentiation of h...
Solid tumors are composed of cancerous cells and non-cancerous stroma. A better understanding of the tumor stroma could lead to new therapeutic applications. However, the exact compositions and functions of the tumor stroma are still largely unknown. Here, using a Lewis lung carcinoma implantation mouse model, we examined the hematopoietic compartments in tumor stroma and tumor-bearing mice. Di...
introduction: acute promyelocytic leukemia treatment revolutionized by new tretamnets. currently number of patinets who undergoe hematopoietic stem cell transplantation decrased so experience with this modality is limited. here we report our experience with stem cell transplantation in acute promyelocytic leukemia patients. design and setting: retrospective, single center methods: between year ...
background nowadays, it has been found that the mental state of caregivers may have a noticeable effect on both patient and caregiver’s health. this study was conducted to determine the burnout and general health status of the hematopoietic stem cell transplantation nurses in tehran, iran. methods in a cross-sectional study, burnout and general health status of 65 hematopoietic stem cell transp...
background: thalassemic patients undergoing hematopoietic stem cell transplantation (hsct) are faced with cumulative high level of oxidative stress and depletion of critical antioxidants. administration of antioxidants, is promising towards minimizing oxidative damage in both thalassemic and hsct patients. method: this was a prospective cross-sectional observational study. patients as a part of...
introduction: the traditional goal of the treatment of acute myelogenous leukemia is to produce and maintain a complete remission (cr).the difference in survival time was entirely attributable to the duration of time spent in cr .in this study, the outcome of aml patients with allogeneic hsct in cr1 versus other than cr1 was compared. patients and methods: since march 1991 until november 2008, ...
objective: to evaluate the potential advantages of imipenem/cilastatin in control of fever in neutro-penic hsct recipients.patients and method: in this single-center study, 111 consecutive febrile episodes in 104 neutropenic hsct recipients with a mean age of 26 years were randomized to treatment either with imipenem/cilastatin 1 g, iv, q8h or cefepime (our standard regimen) 2 g, iv, q8h. if fe...
background: ionizing radiation induces the production of reactive oxygen species (ros), which play an important causative role in cell death. wholebody exposure of mice to gamma radiation leads to diminution of tissue antioxidant defense systems increases the peroxidative damage to membrane lipids and damages the haematopoietic and gastrointestinal systems. tempol (tpl), a cell membranepermeabl...
In patients with acute myeloid leukemia and low percentages of aldehyde-dehydrogenase-positive cells, non-leukemic hematopoietic stem cells can be separated from leukemic cells. By relating hematopoietic stem cell frequencies to outcome we detected poor overall- and disease-free survival of patients with low hematopoietic stem cell frequencies. Serial analysis of matched diagnostic and follow-u...
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