BACKGROUND Continuous 12-lead ECG monitoring (Holter) in early-phase pharmaceutical studies is today widely used as an ideal platform to extract discrete ECGs for analysis. The extraction process is typically performed manually by trained readers using commercial Holter processing systems. METHODS Antares, a novel method for automatic 12-lead extraction from continuous Holter recordings apply...

Heart rate measurement employing photoplethysmography (PPG) is a prevalent technique for wearable devices. However, the acquired PPG signal often contaminated with motion artifacts, which need to be accurately removed. In cases where and accelerometer (ACC) spectra overlap at actual heart rate, traditional discrete Fourier transform (DFT) algorithms fail compute accurately. This study proposed ...

Norepinephrine extraction and spillover rates were determined in the heart and lungs of anesthetized dogs under resting conditions, during sympathetic stimulation, and during epicardial pacing. The fractional extraction of norepinephrine across the coronary and pulmonary vascular beds was measured from the venoarterial difference in tritiated norepinephrine after infusion of a tracer dose to a ...

Background and Objective. Pain evaluation in children can be a difficult task, since it possesses sensory and affective components that are often hard to discriminate. Infrared thermography has previously been used as a diagnostic tool for pain detection in animals; therefore, the aim of this study was to assess the presence of temperature changes during dental extractions and to evaluate its c...

Background: Extraction of Fetal ECG signal from non-invasive abdominal ECG signal is an important clinical application. Fetal ECG signal provides significant and valuable information about the fetal heart growth and health condition. Objective: Abdominal signals are usually corrupted by high amplitude maternal ECG signals and often found superimposed with the Fetal ECG signal. Suppression of ma...

BACKGROUND The relative contributions of decreases in maximal heart rate, stroke volume, and oxygen extraction and of changes in body weight and composition to the age-related decline in maximal oxygen uptake (VO2max) are unclear and may be influenced by sex and level of physical activity. METHODS AND RESULTS To investigate mechanisms by which aging, sex, and physical activity influence VO2ma...