Abstract Background Carcinoid heart disease is an uncommon manifestation of carcinoid syndrome that can present to a cardiac surgeon as complex constellation structural problems. Patients develop progressive valve disease, more commonly the right-sided valves but sometimes involving left, which will in turn impact function. Without intervention, portends dismal prognosis. Given rarity with thes...

The carcinoid syndrome describes the signs and symptoms associated with unregulated vasoactive hormone production by neuroendocrine tumors. Carcinoid tumors can be found anywhere throughout the body, but these will not result in carcinoid syndrome unless they form in the liver as a primary tumor or as a metastasis. Symptoms of carcinoid syndrome include flushing, diarrhea, and wheezing. VIPomas...

Neuroendocrine tumours constitute a group of tumours that originate from neuroendocrine cells throughout the body. That includes endocrine tumours of the thymus, lung, pancreas and gastrointestinal tract. Neuroendocrine gastrointestinal tumours have classically been divided into carcinoid tumours and endocrine pancreatic tumours. Many of these tumours produce hormones that can induce clinical s...

Carcinoid syndrome produces flushing, bronchoconstriction and gastrointestinal hypermotility secondary to serotonin, histamine, bradykinin and prostaglandin release. A variety of drugs, foods and anaesthetic agents may provoke this syndrome. Under anaesthesia, the flushing produced may be associated with acute hypotension and cardiovascular collapse; this phenomenon is called a carcinoid crisis...

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was 'In patients with carcinoid syndrome undergoing valve replacement, will a biological valve have acceptable durability?' Altogether, more than 130 papers were found using the reported search, of which 17 represented the best evidence to answer the clinical question. The authors, jo...

We describe the case of a 76-year-old woman, diagnosed with a neuroendocrine tumor of the cecum in 2004, with liver metastases and carcinoid syndrome since September 2010. The patient had been treated intermittently with chemotherapy cycles, and remained symptomatic, with worsening secondary lesions. In June 2011 she began to present signs and symptoms of right heart failure and was hospitalize...

Gastrointestinal carcinoid tumors date back to 1888 when Otto Lubarsch found multiple tumors in the distal ileum of two patients at autopsy (Lubarsch, 1888). The German pathologist Siegfried Oberndorfer was the first who used the term “Karzinoide Tumoren”, the English translation of which is “carcinoid tumor”. He coined this term because these tumors behaved less aggressively than true carcinom...

Carcinoid heart disease is a rare cause of heart failure with or without right valvular heart impairments. In this study, we showed a case of carcinoid tumour with hepatic metastases inducing carcinoid heart disease. Neuroendocrine heart involvement happens for severe tricuspid valve insufficiency and plaques on right ventricular (RV) walls produced by a release of serotonin (5-HT). A patient a...

BACKGROUND: Carcinoid tumors are the most frequently encountered endocrine tumors of the gastrointestinal tract. They are most often found in the appendix, although they can arise in any location of the gut. Carcinoid tumors may secrete a variety of bioactive substances, which can cause the complex of symptoms associated with the carcinoid syndrome. METHODS: The authors reviewed the pathology, ...