نتایج جستجو برای: hcn4
تعداد نتایج: 319 فیلتر نتایج به سال:
1 Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia Running title: Trafficking-defective HCN4 mutation in cardiac arrhythmia Kazuo Ueda, Kazufumi Nakamura, Takeharu Hayashi, Natsuko Inagaki, Megumi Takahashi, Takuro Arimura, Hiroshi Morita, Yasushi Higashiuesato, Yuji Hirano, Michio Yasunami, Shuichi Takishita, Akira Yamashina, Tohru...
Hyperpolarization-activated cyclic nucleotide-gated (HCN 1-4) channels are the molecular determinants of If/Ih, a mixed cation inward current that controls firing automaticity in pacemaker cells. HCN primarily activated by membrane hyperpolarization, and further regulated cAMP binding to cytosolic nucleotide domain (CNBD). Biochemical measurements ligand purified eukaryotic proteins challenging...
Được mô tả lần đầu năm 1992, hội chứng Brugada (BrS) có tỷ lệ cao ở Châu Á, đặc biệt khu vực Đông Nam Á (5–14/1.000), trong đó Việt Nam. Là nguyên nhân gây ra 4 - 12% cái chết đột tử do tim nam giới dưới 40 tuổi. Nguyên chính biến các gen mã hóa protein kênh điện áp, cho đến nay hơn 300 thể bệnh 19 khác nhau đã được báo cáo. Trong KCND3 và HCN4 đóng một vai trò rất quan trọng việc biểu hiện thô...
BACKGROUND HCN channels activate the pacemaker current I(f), which is thought to contribute significantly to generation and regulation of heart rhythm. HCN4 represents the dominant isotype in the sinoatrial node and binding of cAMP was suggested to be necessary for autonomic heart rate regulation. METHODS AND RESULTS In a candidate gene approach, a heterozygous insertion of 13 nucleotides in ...
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels, primarily their HCN4 subtype, are one of the promising targets for development cardioprotective agents. HCN channel blockers have a selective bradycardic effect, preserving myocardial contractility and diastolic function not affecting electrophysiological parameters heart. This review continues series reviews on analysis compou...
The 'funny' current, also known as the If current, play a crucial role in the spontaneous diastolic depolarization of sinoatrial node cells. The If current is primarily induced by the protein encoded by the hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) gene. The functional If channel can be reconstructed in canine mesenchymal stem cells (cMSCs) transfected with mouse HCN4...
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