Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic infections in individuals suffering from the genetic disorder cystic fibrosis. In P. aeruginosa, the transcriptional regulator AlgR controls a variety of virulence factors, including alginate production, twitching motility, biofilm formation, quorum sensing, and hydrogen cyanide (HCN) production. In this study, the regulati...

Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels on long-term depression (LTD) at the medial perforant path-granule cell synapse in early postnatal (P9-15) and adult (P30-60) rats. LTD was elicited in P9-15 slices using low...

A study to assess the various gases emitted by motorcycles in a metropolitan State, Uyo, in Nigeria was carried out. Two hundred commercial motorcycles the mostly available means of transport were used for the study drawn from seven motorcycle parks. The gases examined were nitrogen dioxide, sulphur dioxide, carbon monoxide, chlorine, hydrogen sulphide and ammonia. The overall collection result...

HCN channels are the molecular subunits of native funny (f-) channels of cardiac pacemaker cells and neurons. Although funny channels were first functionally described in cardiac cells in the late 1970s, cloning of HCN channels, of which four subunits are known today (HCN1-4), had to wait some 20 years to be accomplished, which delayed the investigation of HCN-related channelopathies. In cardia...

Cold-acclimated twigs of Amelanchier alnifolia Nutt. released less HCN at -4.5 C than nonacclimated twigs following slow freezing to -25 C or rapid freezing to -78 C. Cold-acclimated twigs frozen slowly to -25 C released more HCN than cold-acclimated twigs frozen only to -4.5 C. Cold-acclimated twigs frozen slowly to -25 C and then rapidly to -78 C released less HCN at -4.5 C than cold-acclimat...

An n-dimensional hierarchical cubic network (denoted by HCN(n)) contains 2 n n-dimensional hypercubes. The diameter of the HCN(n), which is equal to n+(n+1)/3+1, is about two-thirds the diameter of a comparable hypercube, although it uses about half as many links per node. In this paper, a maximal number of node-disjoint paths are constructed between every two distinct nodes of the HCN(n). Th...

The stem and bulb nematode (Ditylenchus dipsaci) is a serious quarantine pest of vegetables spreading worldwide via seed and planting material. Currently, a hot water technique is used as the pre-seed treatment, which is difficult to execute and the risk of seed damage is high. The objectives of this study were to evaluate the (a) penetration of gaseous hydrogen cyanide (HCN) into garlic tissue...

cAMP signaling in the brain mediates several higher order neural processes. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels directly bind cAMP through their cytoplasmic cyclic nucleotide binding domain (CNBD), thus playing a unique role in brain function. Neuronal HCN channels are also regulated by tetratricopeptide repeat-containing Rab8b interacting protein (TRIP8b), an aux...

The adsorption of methyl isocyanide (CH3NC) and acetonitrile (CH3CN) has been studied on Pd(111). Methyl isocyanide adsorbs on Pd(111) at 80 K at low coverages with the isocyanide functionality oriented close to parallel to the surface; the surface-bound species reorients to a geometry in which the isocyanide group is perpendicular to the surface as the coverage increases. Desorbing the excess ...

Abstract. An imaging survey of CO(1−0), HCN(1−0), and HCO(1−0) lines in the centers of nearby Seyfert galaxies has been conducted using the Nobeyama Millimeter Array and the RAINBOW interferometer. Preliminary results reveal that 3 Seyferts out of 7 show abnormally high HCN/CO and HCN/HCO ratios, which cannot occur even in nuclear starburst galaxies. We suggest that the enhanced HCN emission or...