W ithout the concept of time, there would be no physics, chemistry, or geology, but in medicine, time often gets short shrift. Yet in recent decades a small cadre of clinical investigators has found associations between the body's daily rhythms and the effectiveness of cancer treatment. Working in tandem, biologists have dissected the molecular underpinnings of the human circadian clock, a feed...

The present status of the problem of neutrino mass, mixing and neutrino oscillations is briefly summarized. The evidence for oscillations of atmospheric neutrinos found recently in the Super-Kamiokande experiment is discussed. Indications in favor of neutrino oscillations obtained in solar neutrino experiments and in the accelerator LSND experiment are also considered. Implications of existing ...

In the early 1940s, Roger Sperry cut the optic nerve of a newt, rotated the detached eye 180 ° in its orbit, and assayed the visuomotor behavior of the animal after its nerve had regenerated. The newts, and in subsequent studies, frogs, behaved as if their visual world were back to front and upside down: when a lure was presented in front of them, =they wheeled rapidly to the rear instead of st...

The possible link between infection/inflammation/immune activation and a cancer patient's outcome from both a causative and outcome point of view has long been postulated. Substantial progress in the understanding of tumor-associated antigens/epitopes, immune cellular subpopulations, cytokine pathways/expression, the tumor microenvironment, and the balance between tumor-immune suppression and s...