Octacalcium phosphate (OCP) and hydroxyapatite (HAp) coatings were developed to control the degradation speed and to improve the biocompatibility of biodegradable magnesium alloys. Osteoblast MG-63 was cultured directly on OCP- and HAp-coated Mg-3Al-1Zn (wt%, AZ31) alloy (OCP- and HAp-AZ31) to evaluate cell compatibility. Cell proliferation was remarkably improved with OCP and HAp coatings whic...

The elastic properties of dentin, a biological composite consisting of stiff hydroxyapatite (HAP) nano-platelets within a compliant collagen matrix, are determined by the volume fraction of these two phases and the load transfer between them. We have measured the elastic strains in situ within the HAP phase of bovine dentine by high energy X-ray diffraction for a series of static compressive st...

Hydroxyapatite (Ca10(PO4)6(OH)2; HAp) has been currently used in hard tissue engineering due to its excellent biocompatibility and osteoconductivity [1-3]. However, the brittleness and relatively low mechanical properties of HAp limit its usefulness in bone implants. Thus, much attention has been focused on the hybridization of HAp with suitable polymers in order to obtain high mechanical prope...

Hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) are widely used bioceramics for surgical or dental applications. This paper is dealing with dissolution kinetics of synthetically prepared β-TCP and four types of HAp granules. Two groups of HAp, treated at different temperatures, each of them with two different granule sizes, were tested. Three corrosive solutions with different pH and si...

Micro-carriers are the best known vehicles to transport different kinds of drugs to achieve high impact. In this study, mesoporous magnesium oxide has been harnessed as a micro-carrier to encapsulate the anticancer candidate drug natural-based cubic hydroxyapatite (HAP). HAP@MgO composites with different HAP loading (0-60 wt %), were prepared by a hydrothermal treatment method using triethanol ...

Nontypeable Haemophilus influenzae is a major causative agent of bacterial otitis media in children. H. influenzae Hap autotransporter protein is an adhesin composed of an outer membrane Hapbeta region and a moiety of an extracellular internal 110-kDa passenger domain called Hap(S). The Hap(S) moiety promotes adherence to human epithelial cells and extracellular matrix proteins, and it also med...

Composite of nano-hydroxyapatite (n-HAP) surface grafted with poly(L-lactide) (PLLA) (g-HAP) showed improved interface compatibility and mechanical property for bone fracture fixation. In this paper, in vivo degradation of n-HAP/PLLA and g-HAP/PLLA composite implants was investigated. The mechanical properties, molecular weight, thermal properties as well as crystallinity of the implants were m...

BACKGROUND Conduct problems (CP) and hyperactivity/attention problems (HAP) are thought to covary with regularity, yet few studies have examined their co-occurrence or risk factors that discriminate their trajectories beginning in early childhood. METHOD The present study sought to advance our understanding of this issue by examining separate trajectories of overt CP and HAP symptomatology am...

We investigated how a new type of synthetic porous hydroxyapatite ceramic (HAP-TCP) acts when it is implanted in growing membranous bone. Seventy-six New Zealand White infant male rabbits (4-week-olds) were used. Rabbits received HAP-TCP block or silicone block implantation in their right nasal bone. The left nasal bone was used for a sham. Serial or cross-sectional examinations by morphometry,...

The application of porous hydroxyapatite-collagen (HAp-Collagen) as a bone tissue engineering scaffold is hindered by two main problems: its high cost and low initial strength. As a native 3-dimenssional collagen framework, purified porcine acellular dermal matrix (PADM) has been successfully used as a skin tissue engineering scaffold. Here we report its application as a matrix for the preparat...