Background & Aim:A new sustainable tissue-based system is presented by plant hairy roots, preserving all of the several specialized types of cell with critical roles in allowing bioactive secondary molecules to be synthesized more consistently as usual. The system is also essential for studying the production of alkaloid in culture. Experimental: The ...

Background & Aim:A new sustainable tissue-based system is presented by plant hairy roots, preserving all of the several specialized types of cell with critical roles in allowing bioactive secondary molecules to be synthesized more consistently as usual. The system is also essential for studying the production of alkaloid in culture. Experimental: The ...

June 30, 1986 When Bouroncle and colleagues’ described hairy cell leukaemia as a distinct type of human leukaemia, the methodology for characterising the membrane phenotype of lymphocytes was not yet available. The peculiar morpholo~yofthe hairy cell with its long cytoplasmic villi, well demonstrated by phase contrast microscopy, had some resemblance with that of histiocytes as seen in tissue s...

Hairy cell leukaemia is a rare form of lymphoproliferative disease that affects 2% of leukaemia patients and was first described in 1958 as leukaemic reticuloendotheliosis. The typical presentation is pancytopenia, splenomegaly and abnormal lymphoid cells in blood with hairy cytoplasmic projections. The pathological hairy cell resembles in many ways B-lymphocyte as in chronic lymphocytic leukae...

In this issue of Blood, Dietrich et al report that the low-dose BRAF inhibitor, vemurafenib, is highly effective in refractory hairy cell leukemia. Despite enormous progress that has been made with purine nucleoside analogs as the initial treatment of patients with hairy cell leukemia, the relapse rate and eventual development of refractory disease mandate the continued search for effective new...

4. Ellison D, Sharppe R, Robbins B, et al. Immunomorphologic analysis of bone marrow biopsies after treatment with 2-chlorodeoxyadenosine for hairy cell leukemia. Blood 1994; 84:4310-5. 5. Konwalinka G, Schirmer M, Hilbe W, et al. Minimal residual disease in hairy-cell leukemia after treatment with 2-chlorodeoxyadenosine. Blood Cells Mol Dis 1995; 21: 142-51. 6. Sarmiento M, Scolnik M, Narbaitz...

OBJECTIVES The role of occupational exposures in hairy cell leukaemia was investigated through a multicentre, hospital based, case-control study. This paper analyses the role of exposure to solvents other than benzene in hairy cell leukaemia. METHODS The study included 226 male cases and 425 matched controls, exposure to solvents was evaluated by expert case by case review of the detailed dat...

Paraffin sections of a variety of tissues from 12 patients with typical hairy-cell leukaemia (HCL) were stained for immunoglobulin heavy and light chains by the peroxidase-antiperoxidase (PAP) technique. Plasma cells were frequent, particularly in a lymph node from a severely infected patient. The reactive nature of the plasma cells of HCL was suggested by the fact that there was no restriction...

BACKGROUND Nematode vulva formation provides a paradigm to study the evolution of pattern formation and cell-fate specification. The Caenorhabditis elegans vulva is generated from three of six equipotent cells that form the so-called vulva equivalence group. During evolution, the size of the vulva equivalence group has changed: Panagrellus redivivus has eight, C. elegans six, and Pristionchus p...