The distribution of ofloxacin (OFLX) along the shaft of each of three hair types, i.e., head, axillary and pubic, was investigated and compared among five healthy male volunteers 1 to 4 months after ingestion of OFLX for 1 or 2 days (total dose, 200 or 600 mg). Five strands of each hair type were sectioned together into successive 0.5-cm lengths starting from the dermal end, over a length of < ...

The molecular bases of diseases of the epidermal appendages are gradually being elucidated as genes encoding their constituents and regulation are defined. A direct correspondence between altered protein sequence and aberrant hair shaft structure is evident in cases such as monilethrix (Schweizer, 2006). In others, gene defects lead to altered development and thus perturbed regulation of compon...

To investigate androgen effects on the skin pilosebaceous unit, we studied 21 male-to-female transsexuals and 17 female-to-male transsexuals receiving cross-sex hormones. At baseline and after 4, 8, and 12 months, hair growth was evaluated by the Ferriman-Gallwey score; acne by the Leeds classification; hair growth rate, density, and shaft diameter by image analysis; and sebum production by Seb...

BACKGROUND Current laser hair removal modalities achieve a long-term but not persistent (irreversible) hair loss. OBJECTIVE This review highlights the mechanisms of the current laser hair removal technology and explores possible side effects. METHODS The literature is reviewed. RESULTS The hair shaft plays a key role in the mechanisms underlying current photoepilation procedures by acting...

Introduction The ability to create an organoid, the smallest functional unit of an organ, in vitro across many human tissues and organs is the key to both efficient transplant generation and predictive preclinical testing regimes. The hair follicle is an organoid that has been much studied based on its ability to grow quickly and to regenerate after trauma. Replacing hair lost due to pattern ba...

Hair morphology is one of the most conspicuous features of human variation. The hair follicle has attracted significant attention as a model for the investigation of diverse biological problems. Whereas, very little is known about the genes influencing the morphology and structure of the hair shaft. Curly hair is very common character of hair phenotypes of human, while most congenital curl occu...

TO THE EDITOR The molecular bases of diseases of the epidermal appendages are gradually being elucidated as genes encoding their constituents and regulation are being defined. A direct correspondence between altered protein sequence and aberrant hair shaft structure is evident in cases such as monilethrix (Schweizer, 2006). In others, gene defects lead to altered development and thus perturbed ...

Background: Netherton syndrome is a rare autosomal recessive disorder consisting of ichthyosiform dermatosis, hair shaft abnormalities and an atopic diathesis that presents as widespread erythematous skin. The aim of these reports is emphasis on the importance of the examination of hair as a diagnose route. Case presentation: Case 1: A 6 months old boy with respiratory distress and severe eryth...

Hair from different individuals can be distinguished by physical properties. Although some data exist on other species, examination of the individual molecular differences within the human hair shaft has not been thoroughly investigated. Shotgun proteomic analysis revealed considerable variation in profile among samples from Caucasian, African-American, Kenyan and Korean subjects. Within these ...

Electron micrographs of parts of the sense organ showed that the dendritic axis consisted of a large and a small envelope containing microtubules as their main inclusion. The envelopes are supported by a thick-walled tube believed to be part of the ist-tier sheath cells. The small envelope is segregated from the large envelope near its apex by a fold of the tube wall. The packing of the neurotu...