The phase II detoxification system glutathione transferase (GST) is associated with the establishment of parasitic nematode infections within the gastrointestinal environment of the mammalian host. We report the functional analysis of a GST from an important worldwide parasitic nematode of small ruminants, Haemonchus contortus. This GST shows limited activity with a range of classical GST subst...

Plants containing condensed tannins (CTs) may hold promise as alternatives to synthetic anthelmintic (AH) drugs for controlling gastrointestinal nematodes (GINs). However, the structural features that contribute to the AH activities of CTs remain elusive. This study probed the relationships between CT structures and their AH activities. Eighteen plant resources were selected on the basis of the...

BACKGROUND Haemonchus contortus causes severe economic losses in small ruminants, so this study was conducted to study the UV effect on H. contortus larvae and its protective effect. METHODS Sixteen male goats were divided into 5 groups, control infected, control uninfected and UV 30 minutes exposure; UV 60 minutes exposure and UV booster 60 minutes exposure. The UV groups were exposed to UV ...

Received: Revised: Accepted: August 02, 2013 August 25, 2013 August 29, 2013 This report documents clinical manifestation of anemia associated with Haemonchus spp. in naturally infected llamas from Argentina. Infected animals presented conjunctival pallor, discolored coat, edema in the submandibular area, weakness, lack of exercise tolerance, sternal recumbence and emaciation. The range of hema...

Haemonchus cysteine proteases, because of their apparent critical function in worm physiology, are considered important candidates in the immunological control of haemonchosis in sheep. Only limited information is, however, available on the immunoprotective properties of these molecules in goats. In the present study cysteine proteases of Haemonchus contortus adult worms isolated from a goat st...

Essential oil of Rosmarinus officinalis induces in vitro anthelmintic and anticoccidial effects against Haemonchus contortus Eimeria spp. small ruminants | M Aouadi, E Sebai, A Saratsis, V Kantzoura, K Saratsi, Msaada, S Sotiraki, H Akkari Agricultural Journals

Worm-free Merino yearlings were dosed with either a mixture of infective larvae of Trichostrongylus axei and Ostertagia circumcincta or with O. circumcincta only, and challenged 90-93 days later with infective larvae of Haemonchus contortus. Neither of these methods protected sheep against challenged and slight protection was afforded sheep predosed with T. axei and O. circumcincta and challeng...

While there is some evidence that changes in nicotinic acetylcholine receptor (nAChR) subunits confer resistance to levamisole in gastrointestinal helminth parasites, the exact nature of the resistance mechanism(s) is unclear. We utilised the presence of a resistant fraction within the Wallangra 2003 isolate of Haemonchus contortus larvae in order to subdivide the population into three subpopul...

Controlled-release albendazole capsules (CRCs) are currently registered for use in Australia and New Zealand as anthelmintic treatment in sheep. However, reports on the efficacy of such products on resistant parasite populations are sometimes controversial. This is the first study to report on the efficacy of such products under South African field conditions in sheep harbouring a population of...