DESCRIPTION INVIRASE brand of saquinavir mesylate is an inhibitor of the human immunodeficiency virus (HIV) protease. INVIRASE is available as light brown and green, opaque hard gelatin capsules for oral administration in a 200-mg strength (as saquinavir free base). Each capsule also contains the inactive ingredients lactose, microcrystalline cellulose, povidone K30, sodium starch glycolate, ta...

Two plasmids involved in bacterial virulence, the Escherichia coli plasmid pColV-K30 and the Vibrio anguillarum plasmid pJM1, have been studied with respect to the iron sequestering systems mediated by these two plasmids. Bioassay results show that the two systems are not related functionally because specific iron uptake-deficient mutants in each system cannot be cross-fed by the heterologous b...

This review intends to provide an overview of historical and recent achievements in studies of microbial degradation of natural and synthetic rubber. The main scientific focus is on the key enzymes latex-clearing protein (Lcp) from the Gram-positive Streptomyces sp. strain K30 and rubber oxygenase A (RoxA) from the Gram-negative Xanthomonas sp. strain 35Y, which has been hitherto the only known...

We have investigated a group of bacteriocinogenic strains used in the epidemiological investigation of Klebsiella infections. Transfer of plasmids from these strains to laboratory strains allowed the identification of three klebicins which use the cloacin DF13 receptor in Klebsiella, but are of three distinct immunity types. These klebicins use the ferric-aerobactin receptor determined by ColV-...

Decreased blood supply, high sugar level, and a possibility of bacterial infection in diabetic wounds pose risk for limb loss mortality. Therefore, proper wound care is needed to improve the quality life patients. Vitex trifolia L (Legundi) extract reported have antibacterial antioxidant activity that enhances cell proliferation migration. The antimicrobial hemostatic properties chitosan film a...

BACKGROUND The objective of this study was to evaluate fluid-bed coating as a new technique to prepare a pellet-based solid self-nanoemulsifying drug delivery system (SNEDDS) using cyclosporin A as a model of a poorly water-soluble drug. METHODS The rationale of this technique was to entrap a Liquid SNEDDS in the matrix of the coating material, polyvinylpyrrolidone K30, by fluid-bed coating. ...

In highway and railway foundation projects, the mechanical properties of materials are one main indicators construction process control. The elastic modulus directly affects road surface deflection must be tested. falling ball test method K30 plate load widely used in engineering, order to explore relationship between two methods guide engineering application, applied homogeneous (homogeneous f...

In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for semi-solid 3D printing bone scaffold ibuprofen (IBU) delivery. The cross-linking the obtained performed with 1% glutaraldehyde (GTA) solution, followed by lyophilization. thermal mechanical properties, as well drug release profiles, kinetics prepared scaffolds were investigated. cross-linked lyophilized has ...

Poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. In this study, organic solvent-free solid dispersions (OSF-SDs) containing telmisartan (TEL) were prepared using polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 6000 (PEG 6000) as hydrophilic polymers, sodium hydroxide (NaOH) as an alkalizer, and ...