نتایج جستجو برای: gtn model

تعداد نتایج: 2104793  

Journal: :Pharmacological research 2014
Vincenzo Mollace Carolina Muscoli Concetta Dagostino Luigino Antonio Giancotti Micaela Gliozzi Iolanda Sacco Valeria Visalli Santo Gratteri Ernesto Palma Natalia Malara Vincenzo Musolino Cristina Carresi Saverio Muscoli Cristiana Vitale Daniela Salvemini Francesco Romeo

Bioconversion of glyceryl trinitrate (GTN) into nitric oxide (NO) by aldehyde dehydrogenase-2 (ALDH-2) is a crucial mechanism which drives vasodilatory and antiplatelet effect of organic nitrates in vitro and in vivo. Oxidative stress generated by overproduction of free radical species, mostly superoxide anions and NO-derived peroxynitrite, has been suggested to play a pivotal role in the devel...

Journal: :Circulation research 2003
Andrei L Kleschyov Matthias Oelze Andreas Daiber Yale Huang Hanke Mollnau Eberhard Schulz Karsten Sydow Birgit Fichtlscherer Alexander Mülsch Thomas Münzel

Nitroglycerin (glyceryl trinitrate, GTN) relaxes blood vessels primarily via activation of the soluble guanylyl cyclase (sGC)/cGMP/cGMP-dependent protein kinase (cGK-I) pathway. Although the precise mechanism of sGC activation by GTN in the vascular wall is unknown, the mediatory role of nitric oxide (NO) has been postulated. We tested the GTN/NO hypothesis in different types of isolated rat an...

Journal: :Hypertension 2014
Tea Kaartokallio Miira M Klemetti Anni Timonen Jukka Uotila Seppo Heinonen Eero Kajantie Juha Kere Katja Kivinen Anneli Pouta Päivi Lakkisto Hannele Laivuori

Preeclampsia is a serious and phenotypically heterogeneous vascular pregnancy disorder. Heme oxygenase-1 (HO-1) is a stress response enzyme that may protect the maternal endothelium and facilitate adequate metabolic adaptation to pregnancy by its antioxidant and anti-inflammatory functions. HO-1 stress response is modulated by HO-1 gene (HMOX1) polymorphisms. Individuals with the long allele of...

2009
M Verena Wenzl Matteo Beretta Antonius CF Gorren Pravas K Baral Karl Gruber Michael Russwurm Doris Koesling Kurt Schmidt Bernd Mayer

Background Mitochondrial aldehyde dehydrogenase (ALDH2) plays an essential role in nitroglycerin (GTN) bioactivation, resulting in formation of nitric oxide (NO) or a related activator of soluble guanylate cyclase (sGC) and consequently in cGMP-mediated vasorelaxation [1]. ALDH2 denitrates GTN to 1,2-glyceryl dinitrate (1,2-GDN) and nitrite but also catalyzes reduction of GTN to nitric oxide (N...

Journal: :Applied and environmental microbiology 2001
S J Marshall G F White

Four axenic bacterial species capable of biodegrading nitroglycerin (glycerol trinitrate [GTN]) were isolated from soil samples taken from a washwater soakaway at a disused GTN manufacturing plant. The isolates were identified by 16S rRNA gene sequence homology as Pseudomonas putida, an Arthrobacter species, a Klebsiella species, and a Rhodococcus species. Each of the isolates utilized GTN as i...

Journal: :Brain research 2000
G A Lambert C Donaldson P M Boers A S Zagami

The effect of intra-carotid arterial infusions of glyceryl trinitrate (GTN), a substance known to precipitate headache, including migraine, upon the spontaneous activity of trigeminal neurons with craniovascular input was studied in cats. Second-order craniovascular neurons which received sensory input from the superior sagittal sinus were recorded in the trigeminal nucleus caudalis. Infusions ...

2010
Abdelmonem M. Sharara

Background: Glyceryl Trinitrate (GTN) is a potent smooth muscle relaxant and vasodilator. There are conflicting reports regarding its efficacy as a bronchodilator. The aim of this study was to examine the effect of nebulized GTN on airway calibare and cardio vascular system in normal subjects. Methods: We studied 24 normal subjects (6 female) on two occasions, administering either nebulized GTN...

Journal: :Stroke 2013
Sandeep Ankolekar Michael Fuller Ian Cross Cheryl Renton Patrick Cox Nikola Sprigg A Niroshan Siriwardena Philip M Bath

BACKGROUND AND PURPOSE The practicalities of doing ambulance-based trials where paramedics perform all aspects of a clinical trial involving patients with ultra-acute stroke have not been assessed. METHODS We performed a randomized controlled trial with screening, consent, randomization, and treatment performed by paramedics prior to hospitalization. Patients with probable ultra-acute stroke ...

Journal: :Journal of the American College of Cardiology 2007
Ulrich Hink Andreas Daiber Nalan Kayhan Jordis Trischler Catharina Kraatz Matthias Oelze Hanke Mollnau Philip Wenzel Christian F Vahl Kwok Ki Ho Henry Weiner Thomas Munzel

OBJECTIVES We tested the hypothesis of whether an inhibition of the nitroglycerin (GTN) bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) contributes to GTN tolerance in human blood vessels. BACKGROUND The hemodynamic effects of GTN are rapidly blunted by the development of tolerance, a phenomenon associated with increased formation of reactive oxygen species (ROS). Recent st...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 1998
M F Kearney J F Brien G S Marks H Lei K Nakatsu

The role of nitric oxide (NO) and thiol-containing compounds in glyceryl trinitrate (GTN)-induced vasodilation was investigated using the thiol-alkylating agent N-ethylmaleimide (NEM). Bovine pulmonary artery (BPA) rings were submaximally contracted with K+ and exposed to increasing concentrations of GTN after a 30-min incubation with 50 microM NEM. NEM decreased maximal relaxation (10 microM G...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید