Myosin Va is a well known processive motor involved in transport of organelles. A tail-inhibition model is generally accepted for the regulation of myosin Va: inhibited myosin Va is in a folded conformation such that the tail domain interacts with and inhibits myosin Va motor activity. Recent studies indicate that it is the C-terminal globular tail domain (GTD) that directly inhibits the motor ...

Background and Aim. EUS-guided transmural drainage (EUS-GTD) is now considered a minimally invasive and effective alternative to surgery for drainage of symptomatic pancreatic pseudocysts. However, the technique is rather difficult, and sometimes serious complications occur to patients undergoing this procedure. We retrospectively evaluated efficacy, safety, and long-term follow-up results of E...

randomised non-inferiority trial and meta-analysis. Lancet 2010; 375: 555–562. 4 Creinin MD, Schlaff W, Archer DF, Wan L, Frezieres R, Thomas M, et al. Progesterone receptor modulator for emergency contraception: a randomized controlled trial. Obstet Gynecol 2006; 108: 1089–1097. 5 von Hertzen H, Piaggio G, Ding J, Chen J, Song S, Bártfai G, et al; WHO Research Group on Postovulatory Methods of...

PURPOSE To describe the diffusion-weighted imaging (DWI) appearance of gestational trophoblastic disease (GTD) and to determine its apparent diffusion coefficient (ADC) values. To evaluate the feasibility of DWI to predict progression of hydatidiform mole (HM) to persistent disease. METHODS During a period of 6 months, women with preliminary diagnosis of GTD, based on ultrasound and ßhCG leve...

background: gestational trophoblastic disease (gtd) defines a heterogenenous group of interrelated lesions that arise from the trophoblastic epithelium of the placenta. there are several histologically distinct types of gtd: hydatiform mole (complete or partial), persistant/invasive gestational trophoblastic neoplasia (gtn), choriocarcinoma and placenta site trophoblastic tumors. the aim of thi...

Reinforcement learning (RL) is an essential tool in designing autonomous systems, yet RL agents often require extensive experience to achieve optimal behavior. This problem is compounded when an RL agent is required to learn policies for different tasks within the same environment or across multiple environments. In such situations, learning task models jointly rather than independently can sig...

Three-dimensional electron backscatter diffraction data, obtained by serial sectioning a nickel– base superalloy, has been analysed to measure the geometric arrangement of grain boundary planes at triple junctions. This information has been used to calculate the grain boundary character distribution (GBCD) and the grain boundary energy distribution (GBED). The twin content from the three-dimens...

For nickel-based single crystal superalloy DD6 (AECC Beijing Institute of Aeronautical Materials, Beijing, China) material, a method for predicting creep rupture time was proposed based on newly defined equivalent stress method. An anisotropic model describing the orientation-dependent behavior and lifetime proposed. The subroutine written model. stability improved by adjusting iterative algori...

Gestational Trophoblastic Disease (GTD) in Latin America (LA) has a wide range of presentation and management, depending on socioeconomic, political and geographic variables [1,2,3]. Thus, while some referral centers have sophisticated methods for an early and accurate diagnosis and treatment, still there are a high number of patients admitted with a late Hydatidiform Mole (HM) or advanced Gest...