Parts of this thesis are based on a previous licentiate thesis v To the martyrs of APS attack, Peshawar vi vii Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds, Chem Biol Interact 229 (2015) 91-99. Overexpression of glutathione transferase E7 in Drosophila differentially impacts toxicity of organic isothiocyanates in...

Glutathione S-transferases (GSTs; EC 2.5.1.18) are a multigene family of dimeric multifunctional proteins that play a central role in detoxication of xenobiotic compounds including drugs, herbicides and insecticides [ 11. Based on extensively characterized physicochemical and immunological properties, the mammalian GSTs have been grouped into at least four distinct classes: Alpha, Mu, Pi and Th...

The CREB transcription factor regulates differentiation, survival, and synaptic plasticity. The complement of CREB targets responsible for these responses has not been identified, however. We developed a novel approach to identify CREB targets, termed serial analysis of chromatin occupancy (SACO), by combining chromatin immunoprecipitation (ChIP) with a modification of SAGE. Using a SACO librar...

Glutathione-S-transferases (GSTs) constitute a multifunctional family of dimeric and cytosolic enzymes which play an important role in biotransformation of tissues from oxidative stress. They catalyze the conjugation of intracellular glutathione with chemicals, that possess an electrophilic centre to facilitate their metabolism and elimination through mercapturic acid pathway. Acrylamide, a kno...

In this work, we propose “global style tokens” (GSTs), a bank of embeddings that are jointly trained within Tacotron, a state-of-the-art end-toend speech synthesis system. The embeddings are trained with no explicit labels, yet learn to model a large range of acoustic expressiveness. GSTs lead to a rich set of significant results. The soft interpretable “labels” they generate can be used to con...

A consistent feature of the Alpha-, Mu- and Pi-class glutathione transferases (GSTs) is the presence near the N-terminus of a tyrosine residue that contributes to the activation of glutathione. While this residue appears to be conserved in many Theta-class GSTs, its absence in some suggested that the Theta-class GSTs may have a significantly different structure or catalytic mechanism. The eluci...

Glutathione S-transferases (GSTs) are a major family of detoxification enzymes which possess a wide range of substrate specificities. Most organisms possess many GSTs belonging to multiple classes. Interest in GSTs in insects is focused on their role in insecticide resistance; many resistant insects have elevated levels of GST activity. In the malaria vector Anopheles gambiae, elevated GST leve...

Glutathione S-transferase (GST) isoenzymes represent a large and variable group of antioxidative enzymes, with several different activities and sequence patterns. The GST activities of drought-tolerant Triticum aestivum L. cv. Kobomugi and cv. Plainsman were measured after one week 400 mOsm polyethylene glycol (PEG) treatment. The GST activities were much higher in the root than in the shoot an...

background: glutathione s-transferases ( gsts ) have been investigated as potential carcinoma susceptible genes. however, the relationship between gsts ( gstm1 , gstt1 ) variants and gastric carcinoma (gc) risk has been controversial in chinese population. methods: a comprehensive literature search strategy (pubmed, chinese biomedical database, chinese national knowledge infrastructure, wan fan...

The glutathione S-transferases (GSTs), a family of phase II isozymes, detoxify several carcinogens. Genetic variations in GSTs have been associated with increased risk for cancer due to a heritable deficiency in detoxification pathways for environmental carcinogens. Conflicting findings have been reported about the association between constitutive GST polymorphisms and gliomas in different popu...