Mi(cro)RNAs are small non-coding RNAs of 18-25 nucleotides in length that modulate gene expression at the post-transcriptional level. These RNAs have been shown to be involved in a several biological processes, human diseases and metabolic disorders. Proanthocyanidins, which are the most abundant polyphenol class in the human diet, have positive health effects on a variety of metabolic disorder...

Doxorubicin (Dox) is a common chemotherapeutic anticancer drug. One of its side effect, according to some studies is oxidative stress-induced toxic changes on the liver. In this study protective efficacy of Proanthocyanidin (GSPE) along with vitamin E on Dox induced hepatotoxicity was evaluated in 50 male (divided in to five groups) Wister rats. After 2 weeks of the experiment and drug administ...

OBJECTIVE Tissue damage and endotoxemia in obstructive jaundice are attributed to the increase in oxygen free-radicals. We aimed at evaluating the possible protective effect of grape seed proanthocyanidin extract (GSPE), which is a potent exogenous free-radical scavenger and antioxidant. MATERIAL AND METHODS The study was performed at the Necmettin Erbakan University Meram School of Medicine ...

This paper discusses two common problems, “weld tenting” and low coating thickness over the external weld, and their causes in traditional three layer polyolefin pipeline coatings. To tackle these problems, a new approach to applying multilayer polyolefin coating to pipes is introduced. The new system consists of side-extruding high density polyethylene over a graded structure polyethylene (GSP...