25 In this study, we assessed the acute effects of angiotensin II on the albumin glomerular 26 sieving coefficient (GSC) using intravital microscopy. The experiments were performed on 27 Munich Wistar Froemter (MWF) rats. Alexa-Fluor-594 albumin was injected intravenously, 28 and the fluorescence intensity in the glomerular capillaries and Bowman’s space was 29 determined to calculate the album...

Accumulating evidence indicates that glioblastoma stem-like cells (GSCs) are key factors in tumour development, recurrence and chemoresistance. The impairment of stemness and the enhancement of differentiation contributes to the weakening of radiation and chemotherapy resistance of GSCs. We previously found that β-elemene was an effective anti-glioblastoma agent and chemosensitizer. In this stu...

This paper tackles the speech separation problem in a meeting room using a new acoustic beamforming method – adaptive blocking (AB) beamformer. The proposed method is an optimum beamforming with a structure similar to the generalized sidelobe canceller (GSC) structure, but simpler. Thus, it inherits the flexibility of GSC and functions well in dynamic environments. We investigate the performanc...

The literature on games of strategic complementarities (GSC) has focused on pure strategies. I introduce mixed strategies and show that, when strategy spaces are one-dimensional, the complementarities framework extends to mixed strategies ordered by rst-order stochastic dominance. In particular, the mixed extension of a GSC is a GSC, the full set of equilibria is a complete lattice and the extr...

In this study, we assessed the acute effects of angiotensin II on the albumin glomerular sieving coefficient (GSC) using intravital microscopy. The experiments were performed on Munich Wistar Froemter (MWF) rats. Alexa-Fluor-594 albumin was injected intravenously, and the fluorescence intensity in the glomerular capillaries and Bowman's space was determined to calculate the albumin GSC. The GSC...

Stem cells are maintained in vivo by short-range signaling systems in specialized microenvironments called niches, but the molecular mechanisms controlling the physical space of the stem cell niche are poorly understood. In this study, we report that heparan sulfate (HS) proteoglycans (HSPGs) are essential regulators of the germline stem cell (GSC) niches in the Drosophila melanogaster gonads. ...

Detailed in situ analyses reveal overlapping expression of gsc and Xbra in the early Spemann's organizer. Coexpression is lost during gastrulation suggesting an interaction between these genes. Ectopic expression of gsc ventrally suppresses endogenous Xbra expression and transcription from Xbra promoter reporter gene constructs. Suppression is mediated, at least partially, by a gsc-binding site...

Glioblastoma (GBM) stem cells (GSC) are a subpopulation of tumor cells that display stem-like characteristics (stemness) and play unique roles in tumor propagation, therapeutic resistance, and tumor recurrence. Therapeutic targets in GSCs are a focus of increasing interest to improve GBM therapy. Here we report that the hyaluronan-mediated motility receptor (HMMR) is highly expressed in GBM tum...

We propose a new generalized selection combining (GSC) scheme that selects diversity branches out of ( ) diversity branches based on the magnitude of log-likelihood ratio (LLR), which, for BPSK signals, is proportional to the product of the fading amplitude and the matched filter output. The proposed GSC is shown to provide a significant power gain over the conventional GSC which selects divers...