Chronic myeloid leukemia (CML) is a clonal myeloproliferative disease consisting of chronic phase (CP), accelerated phase (AP) and blast crisis (BC). In recent years, molecular mechanism of CMLBC has been comprehensively investigated. Based on the DNA sequencing, several somatic gene mutations in patients with CML-BC has been revealed. These gene including RUNX1, ASXL1, IKZF1, WT1, TET2, IDH1, ...

We present high-precision measurements of the Nusselt number N as a function of the Rayleigh number R for cylindrical samples of water (Prandtl number σ = 4.4) with a diameter D of 49.7 cm and heights L = 116.3, 74.6, and 50.6 cm, as well as for D = 24.8 cm and L = 90.2 cm. For each aspect ratio Γ ≡ D/L = 0.28, 0.43, 0.67, and 0.98 the data cover a range of a little over a decade of R. The maxi...

This paper summarizes the contribution presented at the IX Marcel Grossmann Meeting (Rome, July 2000). A simple model of spacetime foam, made by N Schwarzschild wormholes in a semiclassical approximation, is here proposed. The Casimir-like energy of the quantum fluctuation of such a model and its probability of being realized are computed. Implications on the Bekenstein-Hawking entropy and the ...

Beale SC (1998) Capillary electrophoresis. Analytical Chemistry 70: 279. (This journal prints every two years a review on capillary electrophoresis. The article is written by an expert in the Reld and covers more or less all developments in CE including CGE of the preceding years.) Grossmann PD and Colburn JC (eds) (1996) Capillary Electrophoresis: Theory and Practice. San Diego: Academic Press...

A wide range of optimization problems arising from engineering applications can be formulated as Mixed Integer NonLinear Programmming problems (MINLPs). Duran and Grossmann (1986) suggest an outer approximation scheme for solving a class of MINLPs that are linear in the integer variables by a nite sequence of relaxed MILP master programs and NLP subproblems. Their idea is generalized by treatin...

Raman and Grossmann (1994) and Lee and Grossmann (2000) have developed a reformulation of Generalized Disjunctive Programming (GDP) problems that is based on determining the convex hull of each disjunction. Although the relaxation of the reformulated problem using this method will often produce a significantly tighter lower bound when compared with the traditional big-M reformulation, the limit...

We present experimental results for the Reynolds number ReU based on the horizontal mean-flow velocity U and for ReV based on the root-mean-square horizontal fluctuation velocity V for turbulent Rayleigh–Bénard convection in a cylindrical sample of aspect ratio Γ = 10.9 over the Prandtl number range 0.18 6 Pr 6 0.88. The results were derived from space–time cross-correlation functions of shadow...

Readers of this volume will notice that it contains only a few papers on general relativity. This is because most papers documenting the genesis and early development of general relativity were not published in Annalen der Physik.After Einstein took up his new prestigious position at the PrussianAcademy of Sciences in the spring of 1914, the Sitzungsberichte of the Berlin academy almost by defa...

Recently it was shown [W. Koch, F. Grossmann, J.T. Stockburger, J. Ankerhold, Phys. Rev. Lett. 100 (2008) 230402] that a combination of an exact stochastic decomposition of non-Markovian dissipative quantum dynamics with the time-dependent semiclassical initial value formalism offers a powerful tool to describe quantum Brownian motion in domains of parameter space where other approaches fail. I...