We demonstrated a method to screen for binders to a particular G-quadruplex sequence using easily designed short peptides consisting of naturally occurring amino acids and mining of binding data using statistical methods such as hierarchical clustering analysis (HCA). Despite the small size of the library used in this study, candidates of specific binders were identified. In addition, a selecte...

Current combinatorial selection strategies for protein engineering have been successful at generating binders against a range of targets; however, the combinatorial nature of the libraries and their vast undersampling of sequence space inherently limit these methods due to the difficulty in finely controlling protein properties of the engineered region. Meanwhile, great advances in computationa...

The aim of this study is evaluating the interaction between several base pen grade asphalt binders (35/50, 50/70, 70/100, 160/220) and two different recycled plastics (EVA and HDPE), for a set of new polymer modified binders produced with different amounts of both recycled plastics. After analysing the results obtained for the several polymer modified binders evaluated in this study, including ...

ceramic ultrafiltration membranes are considered as an alternative for the treatment of both stable water-in-oil and oil-in-water emulsions proved to be more effective in comparison with other conventional techniques. in this study, symmetric macro-porous ceramic membranes are prepared through dry pressing of α-alumina powder and the addition of various binders including poly (vinyl alcohol). t...

A process of micromolding, delivering micro- and nanopatterned ceramic surfaces for biomaterial applications is described in this work. To create the desired structures, tape casting of ceramic slurries on microfabricated silicon mold was used. Several tape casting slurry compositions were tested to evaluate the feasibility of transferring micro- and nano-features from silicon molds. Used ceram...

We report herein the development and preliminary mechanical characterization of fully-dense multi-wall carbon nanotube (MWCNT)-reinforced ceramics and glasses based on a completely new methodology termed High Shear Compaction (HSC). The tubes are introduced and bound to the matrix grains by aid of polymeric binders to form flexible green bodies which are sintered and densified by spark plasma s...

We have investigated the mechanics of individual DNA strands exposed to DNA binding ligands. The interaction of these agents with individual dsDNA strands measured by optical tweezers clearly indicates the ligand-DNA binding mode. As expected, if the compound is intercalating then an increase of contour length is detected. Groove binders affect the overstretching capabilities of the formerly “n...

10.1586/14750708.2.6.823 © 2 Sevelamer hydrochloride is a nonabsorbed, calciumand metal-free phosphate binder, used to bind phosphate and prevent phosphate accumulation in patients with kidney failure. Sevelamer hydrochloride has been an important alternative to calcium-based phosphate binders, because calcium-based binders result in increased gastrointestinal calcium absorption and a positive ...