This article presents a novel 3D printing technique called L-FDM (liquid for fused deposition modeling), which is based on the of molten thermoplastic material. The new method allows direct introduction chemicals and polymer filament modifications during process. In contrast to traditional incremental methods, eliminates need extra granulating, extrusion, processing equipment, making it possibl...

During wet granulation, the sample can be exposed to considerable mechanical effects, moisture content and elevated temperatures, during high-shear granulation impeller chopper speeds induce temperatures influence parameters of products. In our work, we therefore aimed investigate effect cooling process on product by factorial design in accordance with QbD guidelines. Our other goal was study t...

During oxidative burst, neutrophils selectively generate HOCl to destroy invading microbial pathogens. Excess HOCl reacts with taurine, a semi-essential amino acid, resulting in the formation of the longer-lived biogenerated broad-spectrum antimicrobial agent, N-chlorotaurine (NCT). In the presence of an excess of HOCl or under moderately acidic conditions, NCT can be further chlorinated, or it...

OBJECTIVE Growth factors demonstrate mixed results improving wound healing. Amnion-derived multipotent cells release physiologic levels of growth factors and tissue inhibitors of metalloproteinases. This solution was tested in models of acute and chronic wound healing. METHODS Acute model: Sprague-Dawley rats underwent laparotomy incisions. The midline fascia was primed with phosphate-buffere...

BACKGROUND AND PURPOSE The purpose of this study was to compare in patients with spinal cord injury the effect on wound healing of nursing care alone with the effect on wound healing of nursing care combined with either laser treatment or a regimen of ultrasound and ultraviolet-C (US/UVC). SUBJECTS Twenty patients (22 wounds) were randomly assigned to the treatment groups. METHODS All patie...

The effect of screw configuration on granule size distribution (GSD) using gPROMS FormulatedProduct (gFP) software to perform optimization, estimation complex processes, and analyses is evaluated. Twin-screw granulation modeling was used investigate the contribution liquid-to-solid (L/S) ratio GSD. Lactose Avicel were granulating materials. Twelve different configurations investigated under thr...