The graft versus host (GVH) reactivity of Lewis (L) rat spleen cells was measured using a popliteal lymph node (PLN) assay in Lewis-Brown Norway (LBN) recipient rats. Specific sensitization of donors with a single intravenous injection of LBN spleen cells 7-14 days prior to assay resulted in a significant decrease in GVH reactivity. Thirdparty sensitization of donors with Lewis-Buffalo spleen c...

The immunorestorative effect of Cimetidine in vitro on the T cell-induced local GVH reaction in vivo was studied in 43 cancer patients and 43 normal healthy donors. Both low dose (10(-5) M) and high dose (10(-4) M) Cimetidine induced significant, albeit partial, immune restoration among GVHR-negative cancer patients (p less than 0.05, p less than 0.01, respectively) with the high dose being sig...

BACKGROUND Antithymocyte globulin or human Jurkat T-cell-line-derived antilymphocyte globulin is used in allogeneic stem cell transplantation to induce in vivo T-cell depletion to facilitate engraftment and lower graft-versus-host disease. In vitro studies suggest that antithymocyte globulin, besides causing T-cell depletion, has strong anti-myeloma activity. DESIGN AND METHODS We evaluated t...

Despite decades of research, current cancer therapies extend survival but often do not actually cure the disease. Immune cell based therapy is described here that can eliminate tumor cells without the toxicity associated with chemotherapy or allogeneic bone marrow transplant (BMT). Allogeneic BMT has beneficial graft vs. tumor (GVT) effects but accompanied by the undesirable graft vs. host dise...

Recently, evidence has been gathered showing that the H-2 complex of tlic mouse consists of only two histocompatibility genes (regions), H-2K and H-2D (Klein & Shreffler 1972). The rest of the H-2 regions described in the literature (C,V,E,A) are probably serological artifacts. Kychlikovi and co-workers ( 197 1 ) reported that significant transformation of allogeneic lymphocytes in mixed cultur...

discussed, and he points out that merely because a disease is found to be familial in incidence does not mean it is hereditarily transmitted; leprosy, for instance, was long held to be a hereditary disease, and a law was actually proposed in the Norwegian Parliament forbidding the marriage of lepers for that reason. It was only with the discovery of the leprosy bacillus by Hansen that the true ...

* This project is supported by the NSERC of Canada. Abstract An all-new model of the multicast communication is presented in this paper. It utilizes the architecture of the Host Identity Protocol (HIP), which is being defined by the IETF, and two levels of hierarchical administration to achieve secure authentication of the identity of the group members and administration based on the ISP. It is...

Nod-like receptors have emerged as an important family of sensors in host defense. These receptors are expressed in macrophages, dendritic cells and monocytes and play an important role in microbial immunity. Some Nod-like receptors form the inflammasome, a protein complex that activates caspase-1 in response to several stimuli. Caspase-1 activation leads to processing and secretion of pro-infl...

This paper attempts to predict the onset of chronic Graft vs. Host Disease (GVHD) in children with blood cancers who have received a bone marrow or stem cell transplant using machine learning models. It analyzes and compares results three different models terms how accurate they each are predicting GVHD. These Logistic Regression, J48 algorithm decision trees, Multilayer Perceptron. The formed ...

Graft-vs.-host (GVH) reactions were performed in chicken embryos by intravenous injection of adult chicken blood dilutions, and the result was scored by weighing the spleens as well as by karyological identification of host and donor metaphases. From the frequency of detectable signs of GVH reaction when low doses of donor cells were injected into hosts containing one foreign allele of the B lo...