نتایج جستجو برای: gonadotoxicity
تعداد نتایج: 77 فیلتر نتایج به سال:
Background The impact of cancer therapy on the reproductive potential of patients is increasingly recognized because survival rates of patients have clearly improved in recent years. The study stressed the use of AMH may allow better prediction of chemotherapy-related risk to further fertility. MaterialsAndMethods A narrative review was performed within articles published at PubMed, Elsevier, S...
Background: We aimed to assess the long-term toxic effects of sulphur mustard (SM) on the testis and male fertility two decades after exposure. Materials and Methods: A historical cohort study was conducted in 2005. Sixty-four SM-exposed and 64 matched SMunexposed casualties of the Iraq–Iran conflict were enrolled. Fecundity status, semen indices, hormonal assay results and testis histopatholog...
Abstract Background Preventing premature ovarian failure (POF) is a major challenge in oncology. With conventional regimens, cytotoxicity-associated POF involves primordial follicles (PF) pool depletion by apoptosis or overactivation mechanisms, notably mediated the ABL/TAp63 and PI3K/Akt/mTOR pathways. New anticancer treatments have been designed to target pathways implicated tumor growth. Alt...
STUDY QUESTION Do different chemotherapy drugs exert the same magnitude of cytotoxicity on dormant primordial follicles and the growing follicle fraction in the ovary in vivo and on mitotic non-luteinized and non-mitotic luteinized granulosa cells in vitro? SUMMARY ANSWER Cyclophosphamide (alkylating agent) and cisplatin (alkylating like) impacted both primordial and pre-antral/antral follicl...
The term “childhood cancer” is used to designate neoplasms arising before 15 years of age (Stewart and Wild, 2014). These represent between 0.5% and 4.6% of the total number of cancer cases worldwide, being greater in countries with low human development (Stewart and Wild, 2014). Between 2008 and 2014, there was an increase of approximately 3,000 cases of childhood cancer world wide (Stewart an...
BACKGROUND With the continuous improvement of surgery and chemotherapeutic treatments, many tumour patients increasingly achieve long-term survival and can even be completely cured. However, platinum-containing drugs, which are widely used to treat a variety of types of cancer, cause menstrual disorders and ovarian failure, which in turn lead to infertility. Thus far, gonadotropin releasing hor...
BACKGROUND Germ cell depletion caused by chemical or physical toxicity, disease or genetic predisposition can occur at any age. Although semen cryopreservation is the first reflex for preserving male fertility, this cannot help out prepubertal boys. Yet, these boys do have spermatogonial stem cells (SSCs) that able to produce sperm at the start of puberty, which allows them to safeguard their f...
Background: In this consensus-based position paper, the scientific societies Fondazione Italiana Linfomi (FIL) and Società della Riproduzione Umana (SIRU) reviewed main aspects identified optimal paths aimed to preserve monitor fertility in patients diagnosed with lymphoma. Methods: The multi-disciplinary working group for paper was composed by 5 onco-hematologists, 4 gynecologist or andrologis...
Approximately 40 000 adolescent and young adult females between the ages of 15 and 39 years are diagnosed with cancer yearly. The high survival rate ofmany cancers has broadened the focus of what is considered an optimal clinical outcome to include preservation of ovarian function. Ovarian function has many implications for the cancer survivor including fertility, bonehealth andpsychosocial wel...
Abstract Study question Does verteporfin, an inhibitor of YAP/TAZ activity, prevent from the impacts chemotherapy exposure on signaling pathways governing follicle activation and survival? Summary answer Verteporfin treatment prevents chemotherapy-induced impairments Hippo pathway but also PI3K survival pathways. What is known already The a crucial regulator ovarian reserve. Disruption this occ...
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