We describe a new approach for glucose determination with tunable glucose dynamic sensing ranges, dependent on the properties of new nanosensors, which are comprised of Con A-aggregated dextran-coated gold colloids. Dextran-coated 10 or 20 nm gold colloids can be aggregated with Con A in a controlled fashion, the change in absorbance at an arbitrary wavelength used to monitor the extent of aggr...

The transfer of molecules from the cell surface to the early endosomes is mediated by preendosomal vesicles. These vesicles, which have pinched off completely from the plasma membrane but not yet fused with endosomes, form the earliest compartment along the endocytic route. Using a new assay to distinguish between free and cell surface connected vesicle profiles, we have characterized the preed...

Well-known surface properties of gold nanoparticles (AuNPs) offer easy surface modification with desired biomolecule, thus enabling them to be used for targeting and imaging of cancer cells/tissues. However, targeting and imaging capability come through after synthesis coating of AuNPs' surface with targeting or imaging molecules. Attempts have been made to conjugate both imaging and targeting ...