a Unidad de Hepatología, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, España b Unitat de Suport a la Recerca (USR) Metropolitana Nord, Institut d’Investigació en Atenció Primaria (IDIAP) Jordi Gol, Centro de Investigación en Red de Enfermedades Hepáticas y Digesti...

Lampreys are extant representatives of agnathans. Descriptions of lamprey development, physiology and genome have provided critical insights into early evolution of vertebrate traits. However, efficient means for genetic manipulation in agnathan species have not been developed, hindering functional studies of genes in these important Evo-Devo models. Here, we report a CRISPR/Cas system optimize...

Situations are entities that have been discussed in philosophy, ontology and computer science for applications in the field of knowledge representation, conceptual modelling and natural language semantic. On the basis of an extensive literature review, situations and entities we call situoids, which are more basic than situations, will be discussed and their ontological features investigated. A...

Oriented samples of the Lov.'er Cambrian Sayan Go! Formation from Salaany Go!, Mongolia, were collected at roughly 5 m stratigraphic intervals for palaeomagnetic analysis. Progressive alternatingfield and thermal demagnetization isolated two magnetic components: a present-field overprint, typically removed by 10 mT fields and -200 °C heating: and a high-coercivity, high-unblocking-temperature (...

BACKGROUND Psoriatic arthritis (PsA) is a chronic inflammatory arthritis which impacts significantly on the quality of life and work capacity of affected individuals. Recent evidence has shown that early control of inflammation in PsA leads to improved long-term outcomes. It is postulated that prompt intervention after diagnosis using a remission-induction treatment strategy will lead to improv...

The two-point based sampling technique was introduced by Chor and Gol-dreich with the purpose of reducing the amount of randomness needed in ran-domized algorithms. It has since found numerous applications in theoretical computer science. In this note, we point out a connection between two-point based sampling and the combinatorial structures known as orthogonal arrays. We also present an eleme...

A new gem corundum occurrence has been discovered in the Naryn-Gol Creek placer of Dzhida volcanic field (Russia). In this deposit, sapphire associates with large crystals garnet, spinel, augite, olivine, enstatite, ilmenite, Ti-magnetite, and alkali feldspar. Such a combination minerals is typical for deposits associated basalts widely distributed Southeastern Asia Australia. We have also foun...