Retrosternal goitre is defined as a goitre with a portion of its mass > or = 50% located in the mediastinum. Surgical removal is the treatment of choice and, in most cases, the goitre can be removed via a cervical approach. Aim of this retrospective study was to analyse personal experience in the surgical management of retrosternal goitres, defining, in particular, the features requiring sterno...

Endemic goitre has been reported in the climatic wet zone of south-west Sri Lanka for the past 50 years, but rarely occurs in the northern dry zone. Despite government-sponsored iodised salt programmes, endemic goitre is still prevalent. In recent years, it has been suggested that Se deficiency may be an important factor in the onset of goitre and other iodine deficiency disorders (IDD). Prior ...

Despite a successful national salt iodinization programme, endemic goitre still persists in Iranian children. In a cross-sectional study in Arak the prevalence of goitre was 5.2% in a sample of 6520 primary-school children. Subsamples of 193 children with goitre and 151 healthy children were assessed for urinary iodine excretion, thyroid hormone profile, insulin-like growth factor-1 (ICF-1) and...

Ninety-seven fixed surgical thyroid specimens and 63 unfixed and 40 fixed thyroid specimens from autopsies were examined for their oxalate content. Proteases were used to process the tissue, and the oxalate was determined with an enzymatic assay. The fixed samples were grouped into seven diagnostic categories (diffuse colloid goitre; partially diffuse, partially nodular colloid goitre; nodular ...

OBJECTIVE To determine how iodine deficiency and endemic goitre disappeared in Britain. DESIGN Review of surveys of endemic goitre and iodine nutrition. MAIN RESULTS Endemic goitre was widespread in Britain but has declined, most notably since the 1960's. Its disappearance was probably due to changes in farming practice, especially iodine supplementation in dairy herds which has resulted in...

In the course of medical inspection of school children of Mulepur, a village in Kabirwala talisilit was noticed that a remarkably larg-e number of children suffered from simple goitre. Out of a total number of 70 boys examined, 32 were found to be suffering from goitre?a very high percentage. Further investigation showed that goitre exists not only amongst the students of the 1st and 5th classe...

The relationship between thyroid auto-immunity and the presence of lymphocytes in the thyroid gland has been analysed in patients with Graves' disease, toxic adenoma, and non-toxic nodular goitre. In all these conditions circulating antibody to thyroglobulin was significantly associated with lymphocytic infiltration. No similar correlation was established in the case of the complement-fixing an...