نتایج جستجو برای: gnrh a

تعداد نتایج: 13434160  

Journal: :Molecular endocrinology 2007
Samuel Quaynor Lian Hu Po Ki Leung Hao Feng Nadia Mores Lazar Z Krsmanovic Kevin J Catt

The G protein-coupled receptor 54 (GPR54) and its endogenous ligand, kisspeptin, are essential for activation and regulation of the hypothalamic-pituitary-gonadal axis. Analysis of RNA extracts from individually identified hypothalamic GnRH neurons with primers for GnRH, kisspeptin-1, and GPR54 revealed expression of all three gene products. Also, constitutive and GnRH agonist-induced biolumine...

Journal: :Reproductive biology 2010
Magdalena Ciechanowska Magdalena Lapot Krystyna Mateusiak Franciszek Przekop

This review is focused on the relationship between neuroendocrine regulation of GnRH/LH secretion and the expression of GnRH and GnRH receptor (GnRHR) genes in the hypothalamic-pituitary unit during different physiological states of animals and under stress. Moreover, the involvement of hypothalamic GABA-ergic, Beta-endorphinergic, CRH-ergic, noradrenergic, dopaminergic and GnRH-ergic systems i...

Journal: :International journal of oncology 2015
Marina Montagnani Marelli Marilena Manea Roberta M Moretti Monica Marzagalli Patrizia Limonta

It is well established that gonadotropin-releasing hormone receptors (GnRH-R) are expressed in different types of cancers, including castration-resistant prostate cancer (CRPC) and mediate the antiproliferative effect of GnRH analogs. Thus, these compounds are employed as targeting moieties to selectively deliver chemotherapeutic agents to cancer cells. GnRH-III, the decapeptide isolated from t...

Journal: :Development 2005
Kathleen E Whitlock Kalmia M Smith Hannah Kim Maegan V Harden

Gonadotropin-releasing hormone (GnRH) is found in a wide range of vertebrate tissues, including the nervous system. In general, GnRH has two functions: endocrine, acting as a releasing hormone; and neuromodulatory, affecting neural activity in the peripheral and central nervous system. The best understood population of GnRH cells is that of the hypothalamus, which is essential for reproduction....

Journal: :Endocrinology 2007
Colleen A Flanagan Chun-Chun Chen Marla Coetsee Sipho Mamputha Kathleen E Whitlock Nicholas Bredenkamp Logan Grosenick Russell D Fernald Nicola Illing

Multiple GnRH receptors are known to exist in nonmammalian species, but it is uncertain which receptor type regulates reproduction via the hypothalamic-pituitary-gonadal axis. The teleost fish, Astatotilapia burtoni, is useful for identifying the GnRH receptor responsible for reproduction, because only territorial males reproduce. We have cloned a second GnRH receptor in A. burtoni, GnRH-R1(SHS...

Journal: :Neuropeptides 1985
N M Sherwood S A Sower

The two living representatives of the most ancient vertebrates, Agnathans, are lamprey and hagfish. Using immunological methods, we identified gonadotropin-releasing hormone (GnRH)-like molecules in the lamprey brain, but not hagfish. The lamprey GnRH was detected poorly by antisera directed at the C-terminus, suggesting that a C-terminal amino acid substitution may have occurred in the lamprey...

Journal: :Endocrinology 2011
Heidi Chan Melanie Prescott ZhiYi Ong Michel K Herde Allan E Herbison Rebecca E Campbell

GnRH neuron activity is dependent on gonadal steroid hormone feedback. Altered synaptic input may be one mechanism by which steroids modify GnRH neuron activity. In other neuronal populations, steroid hormones have been shown to elicit profound effects on dendritic spine density, a measure of excitatory synaptic input. The present study examined gonadal steroid feedback effects on GnRH neuron s...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Lazar Z Krsmanovic Nadia Mores Carlos E Navarro Krishan K Arora Kevin J Catt

The pulsatile secretion of gonadotropin-releasing hormone (GnRH) from normal and immortalized hypothalamic GnRH neurons is highly calcium-dependent and is stimulated by cAMP. It is also influenced by agonist activation of the endogenous GnRH receptor (GnRH-R), which couples to G(q/11) as indicated by release of membrane-bound alpha(q/11) subunits and increased inositol phosphate/Ca(2+) signalin...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Sheng Wu Sara Divall Gloria E Hoffman Wei Wei Le Kay-Uwe Wagner Andrew Wolfe

Gonadotropin-releasing hormone (GnRH) neurons represent the final common output of signals from the brain that regulates reproductive function. A wide range of environmental factors impact GnRH neuron activity including disease, stress, nutrition, and seasonal cues, as well as gonadal steroid hormones. The CNS response is thought to be mediated, at least in part, through intermediate signaling ...

Journal: :American journal of physiology. Endocrinology and metabolism 2011
John L Frattarelli Lazar Z Krsmanovic Kevin J Catt

In perifused immortalized GnRH neurons (GT1-7), simultaneous measurements of GnRH and cAMP revealed that the secretory profiles for both GnRH and cAMP are pulsatile. An analysis of GnRH and cAMP pulses in 16 independent experiments revealed that 25% of pulses coincide. Inversion of the peak and nadir levels was found in 33% and random relationship between GnRH and cAMP found in 42% of analyzed ...

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